LUBIPROSTONE: A NOVEL DRUG TO TREAT CONSTIPATION
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2013, Vol 1, Issue 2
Abstract
Lubiprostone, a bicyclic fatty acid, is a novel drug of new class of agents called prostones. It is approved by US FDA for the treatment of chronic constipation and constipation associated irritable bowel syndrome (IBS-C). It activates specific chloride channels in the gastrointestinal tract to stimulate intestinal fluid secretion, increase gastrointestinal transit and improve symptoms of constipation. Lubiprostone is well tolerated in majority of the patients with nausea being the most common adverse effect. Lubiprostone represents a new approach of treatment in cases of resistant or intolerable cases of chronic constipation with proven efficacy and safety.
Authors and Affiliations
Kamlesh Garg*| Assistant Professor, Department of Pharmacology, VMMC and Safdarjung Hospital, New Delhi, Surinder Kumar| Medical officer, Department of Anesthesia, VMMC and Safdarjung Hospital, New Delhi, Ruchika Nanda| Assistant Professor, Department of Pharmacology, Dr HSJ Institute of Dental Sciences, Panjab University, Chandigarh, Suraj B| Junior Resident, Department of Pharmacology, VMMC and Safdarjung Hospital, New Delhi
Keywords
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