“Marchiafava-Bignami Disease InANonalcoholic Younge Male:A Rare Disease”
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Marchiafava-Bignami disease (MBD) is a rare neurological disorder mostly seen in chronic alcoholic and malnourished patient with pathological hallmark of corpus callosum demyelination and necrosis. We report a case of marchiafava bignami disease in a chronic kidney disease patient, without alcoholism or malnutrition. A 20-year-old man presented with sudden onset of altered sensorium with multiple falls in three days. Neurologic examination showed dysarthria and ataxia but, otherwise, normal cranial nerves, motor and sensory functions, and tendon reflexes. Brain MRI showed symmetric abnormalities in the corpus callosum. In addition, demyelination was also observed in subcortical white matter in bilateral lateral frontal lobes. His symptoms significantly improved after stabilization and normalization of his serum creatinine level after a dialysis. The underlying pathophysiology of the development of MBD in our case is likely to be osmotic stress from chronic kidney disease causing structural and functional disturbance of oligodendrocytes.
Authors and Affiliations
Dr. Sweety Thakker, Dr. P. A. Amin
Keywords
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