Metabolic Syndrome: Definition and Pathophysiology– the discussion goes on!
Journal Title: Journal of Physiology and Pharmacology Advances - Year 2013, Vol 3, Issue 3
Abstract
There are a number of official definitions of Metabolic Syndrome; still there is an ongoing international debate on its existence. Metabolic syndrome is the result of highly complex interplay of a number of risk factors and not a single etiology can be assigned to it. Genetic predisposition and environmental risk factors are responsible for predisposition to the syndrome. The insight into the pathophysiology of metabolic syndrome provide a practical tool to identify patients with an increased risk of cardiovascular disease (CVD) and diabetes mellitus type 2. Increased prevalence of the syndrome affecting quarter of the world population, might be a consequence of worldwide obesity epidemic, ageing population and increased insulin resistance.. Identification of metabolic syndrome is a public health strategy to define susceptible people, which may prompt early diagnosis of previously undetected components of metabolic syndrome. Simple life style modifications specifically at the preliminary stage of the syndrome like weight reduction, regular exercise, diet modification, decreasing the effect of insulin resistance by these modifications or drug treatment is promising in decreasing the risk of CVD and type 2 diabetes. This reference article gives a balanced overview of the current knowledge of the various definitions, pathophysiology, genetics and association between different risk factors. Keywords: Pathophysiology, Cardiovascular disease (CVD), Type 2 Diabetes Mellitus, Risk factors, Genetics.
Authors and Affiliations
R. G. Thaman , G. P. Arora
Keywords
Related Articles
- EP ID EP115229
- DOI -
- Views 118
- Downloads 0
A Comparative Study of Intraocular Pressure in Emmetropic and Myopic Subjects in Raichur City
Myopia is one of the most growing problems worldwide. It is now generally accepted that there is increased prevalence of glaucoma among myopic eyes. Several studies concluded that myopic eyes have 1.6 to 3.3 times increa...
Relationship and Distribution of ABO, Rh Blood Groups and Hemoglobin Concentration among the Adolescents
Anemia is a global problem and at its worst in developing countries. It is suggested that the oral supplementation of iron is not the best way to correct anemia (especially which are not due to iron deficiency) due to it...
Decrease Effect of Vitis Vinifera Leave Hydro-Alcoholic Extract on Reproductive Parameters In Adult Normal Male Rats
Grape leaves are used in a traditional food and for treatment of diarrhea, bleeding; and also reported that administered grape was good to treatment of constipation, gout and etc. So, the aim of this study was to investi...
Effect of Intra-Uterine Growth Retardation on Umbilical Cord Blood Thyroid Hormone Level
The present endeavor is an attempt to see the influence of IUGR on umbilical cord plasma thyroid hormone level in order to sort out some ideas about the far-reaching consequence of growth retardation on the development o...
Effect of Lepidium sativum on Lipid Profiles and Blood Glucose in Rats
The present study was designed to investigate the effects of Lepidium sativum on the blood glucose and lipid profile in hypercholesterolemic rats. Fourty adult albino male rats were classified into three groups. One was...