NANOSUSPENSIONS TECHNOLOGY IN DRUG DELIVERY – A REVIEW
Journal Title: Int J of Pharm Rev& Res - Year 2012, Vol 2, Issue 1
Abstract
Nanosuspensions is colloidal dispersions of nanosized drug particles stabilized by surfactants. They can also be defined as a biphasic system consisting of pure drug particles dispersed in an aqueous vehicle in which the diameter of the suspended particle is less than 1 μm in size. Nanosuspensions can be used to enhance the solubility of drugs that are poorly soluble in aqueous as well as lipid media. As a result, the rate of flooding of the active compound increases and the maximum plasma level is reached faster. This review focused on unique advantages of Nanosuspensions, which it has over other approaches for enhancing solubility. It is useful for molecules with poor solubility, poor permeability or both, which poses a significant challenge for the formulators. Nanosuspensions differ from Nanoparticles, which are polymeric colloidal carriers of drugs (Nanospheres and nanocapsules), and from solid-lipid nanoparticles (SLN), which are lipidic carriers of drug
Authors and Affiliations
*Ramaiyan Dhanapal , 1J. Vijaya Ratna
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