A COMPARATIVE STUDY OF ORAL EPITHELIUM IN TOBACCO AND ALCOHOL CONSUMERS BASED ON HABIT INDEX
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 37
Abstract
[b]BACKGROUND AND OBJECTIVE[/b]: The regular use of tobacco and alcohol cause similar effects on oral mucosa like loss of cell cohesion, hyperkeratosis, and increased incidence of nuclear anomalies. The study was conducted to observe the impact of tobacco and alcohol on the nuclear changes in oral epithelial cells in 800 subjects ranging from 20 to 70 years in age. Methods: The nuclear aberrations such as multinucleation, binucleation, pyknosis, karyorrhexis and karyolysis in papanicolaou stained buccal smears of the patients attending OPD at ENT, Gastroenterology, TB & Chest Disease, Medicine, Surgery and Radiotherapy departments, JLN Medical College and attached hospitals, Ajmer, were evaluated. Results: Mean Habit Index of alcohol and tobacco users observed was 235485.82±450581.39. A statistical significant result was found between frequency of nuclear changes and various habit indices viz: multinucleation with chewing index, alcoholic + smoking index, smoking+ tobacco chewing index; binucleation with alcoholic +tobacco chewing index; karyorrhexis with alcoholic +tobacco chewing index, smoking+ tobacco chewing index; karyolysis with chewing index, smoking+ tobacco chewing index; pyknosis with smoking index, alcoholic + smoking index, smoking+ tobacco chewing index, alcoholic + smoking + tobacco chewing index. Conclusion: Microscopically examined nuclear changes are a useful tool in early diagnosis of the oral carcinoma.
Authors and Affiliations
Vijay Sharma, Aarushi Jain, Vijeta Sharma
Keywords
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- EP ID EP101062
- DOI 10.14260/jemds/1268
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