Classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers: A comparative study
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2015, Vol 5, Issue 1
Abstract
Background: The incidence of autonomic dysfunction has increased in the presence of type 2 diabetes mellitus and various tools have been developed for assessing it. Classical autonomic function tests are one among them. Aims & Objectives: To compare the classical autonomic function tests in patients with type 2 diabetes mellitus and healthy volunteers. Materials and Methods: This study was conducted at the PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India, on 30 patients with type 2 diabetes mellitus (cases) and 30 healthy volunteers (controls). Average age of the patients with diabetes mellitus was 48.53 ± 5.12 years (mean ± SD) and that of the volunteers was 47.10 ± 3.59 years (mean ± SD). After obtaining informed, written consent, cardiorespiratory parameters such as resting heart rate (HR), systolic blood pressure, and diastolic blood pressure were measured after 10 min of supine rest. Autonomic function parameters such as HR and blood pressure response to handgrip, deep breathing difference test, and Valsalva ratio were recorded in them. Results: Statistical analysis was carried out using independent Student’s t-test, which showed a statistically significant impairment in HR response to handgrip (P < 0.001), blood pressure response to handgrip (P < 0.001), deep breathing test (P < 0.001), and Valsalva ratio (P < 0.001). Conclusion: Results of this study showed that significant impairment was present in patients with type 2 diabetes than in healthy volunteers, and it was more pronounced for parasympathetic system than for sympathetic system.
Authors and Affiliations
Mohan Jayabal, Dinesh Thangavel, Uma Maheswari Thiyagarajan, Nagashree Ramasamy, Venkatesan Rangan, Venkidusamy Subramaniyam
Keywords
Related Articles
- EP ID EP90769
- DOI 10.5455/njppp.2015.5.160820141
- Views 124
- Downloads 0
A study on the effect of atorvastatin on the pharmacokinetic and antidepressant activity of fluoxetine
Background: Polypharmacy is of wide concern in drug interaction. It is the leading cause of adverse drug reaction, and consequently, increasing the possibility of hospitalization and escalating the cost of care. The inci...
Comparative analysis of choice reaction times with randomly variable foreperiods in normal individuals and schizophrenic patients
Background: Reaction time (RT) is an index of brain’s biological efficiency. RT can indicate sensorimotor variability with varying foreperiods (FPs) and can indicate mental dysfunction like schizophrenia. Aims and Object...
Effect of obesity on median nerve conduction at carpal tunnel level in Indian women
Background: Nerve conduction study (NCS) is essential in the diagnosis of focal neuropathies and diffuse polyneuropathies. There are many reasons of variations in nerve conduction velocity (NCV). Age, height, and body...
A randomized open-label study to compare the effects of amlodipine and cilnidipine on heart rate and proteinuria in subjects with hypertension with proteinuria
Background: Calcium channel blockers (CCBs) are a commonly used class of drugs for the treatment of hypertension. Cilnidipine is a novel CCB with a dual L/N-type CCB property, thus favoring additional renal and cardiovas...
Dapsone hypersensitivity syndrome - A case report
Dapsone is widely used for the treatment of leprosy and other immunological and inflammatory dermatological conditions such as dermatitis herpetiformis, vesiculobullous dermatoses, and pustular psoriasis. Dapsone hyperse...