EFFECT OF ORAL CLONIDINE PREMEDICATION ON INTRAVENOUS ANAESTHETICS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2013, Vol 2, Issue 30
Abstract
[b] OBJECTIVES[/b]: To study the effect of oral clonidine premedication on the induction doses of intravenous thiopentone sodium and propofol. [b]METHODS[/b]: After ethical committee approval and informed consent, 120 ASA grade I and II patients were randomly allocated to four groups of 30 each. Group A received a placebo orally, 90 minutes before induction with thiopentone. Group B received clonidine 4µg/kg orally, 90 minutes before induction with thiopentone. Group C received a placebo orally, 90 minutes before induction with propofol. Group D received clonidine 4µg/kg orally, 90 minutes before induction with propofol. The patients were premedicated with Tab Diazepam 5 mg orally on the night before surgery. Inj. Glycopyrrolate 0.004 mg/kg IV was administered before starting anaesthesia. The patients were pre-oxygenated with 100% oxygen for 3 minutes and anaesthesia was induced with either thiopentone sodium 2.5% or propofol, slowly till loss of eyelash reflex was achieved. The dose of either thiopentone sodium or propofol required for induction of anaesthesia was noted. Inj. Succinylcholine 1.5 mg/kg was injected intravenously to facilitate tracheal intubation and after intubation anaesthesia was continued in the conventional manner. The heart rate and blood pressure were recorded throughout the procedure. [b]RESULTS:[/b] The dose of thiopentone sodium required for induction was significantly lower by 21.3% in the group B (3.65±0.3 mg/kg) as compared with the control group A (4.64±0.35 mg/kg), effect size, d=2.02, p<0.001. The dose of propofol required for induction was significantly lower by 16.01% in the group D (1.73±0.08 mg/kg) as compared with the control group C (2.06±0.06 mg/kg), effect size, d=0.92, p=0.001.[b] CONCLUSION[/b]: Oral clonidine premedication decreases the induction doses of both thiopentone sodium and propofol.
Authors and Affiliations
Pradeep M. S, Prabha P
Keywords
Related Articles
- EP ID EP90173
- DOI 10.14260/jemds/1032
- Views 110
- Downloads 0
SPLIT-COURSE ACCELERATED HYPERFRACTIONATED RADIOTHERAPY IN HEAD AND NECK CARCINOMA- AN EXPERIENCE IN TERMS OF LOCAL TUMOUR CONTROL AND TOXICITY
BACKGROUND Radiotherapy alone was long the standard nonsurgical therapy for locally advanced disease. A recent meta-analysis of randomised trial testing modified fractionation schemes against conventional once-daily frac...
ASSESSMENT OF NUTRITION STATUS IN PREOPERATIVE SURGICAL PATIENT UNDERGOING MAJOR ABDOMINAL SURGERIES AND ITS RELATION TO POSTOPERATIVE OUTCOME
BACKGROUND Abdominal surgery represents a premeditated trauma, which leads to nutritional depletion and its possible related adverse outcomes, especially in malnourished pre-operative patients. Hence, the aim of the stud...
PLATELET INDICES AS USEFUL INDICATORS OF NEONATAL SEPSIS
BACKGROUND Neonatal sepsis is a disease process, which represents the consequences of systemic response to bacteria entering the blood stream during the first 28 days of life. Platelet count (PLT) and indices, including...
USE OF ECG AND OTHER CLINICAL VARIABLES FOR DETECTING PULMONARY HYPERTENSION IN COPD PATIENTS- A CROSS-SECTIONAL OBSERVATIONAL STUDY
BACKGROUND Chronic Obstructive Pulmonary Disease (COPD) has emerged as a leading cause of mortality worldwide. Pulmonary Hypertension (PH) is a frequent complication associated with COPD and it is prevalent among 10% - 3...
EVALUATION OF CBNAAT IN THE DIAGNOSIS OF SMEAR NEGATIVE TUBERCULOSIS IN A TERTIARY CARE HOSPITAL
BACKGROUND Tuberculosis is world’s one of the deadliest communicable diseases, which requires early diagnosis and treatment. As smear confirmation requires at least 10000 bacilli/mL and conventional culture methods take...