FENOTEROL BETA- AGONIST ON CONTRACTION AND RELAXATION OF INTESTINAL SMOOTH MUSCLE OF MALE ALBINO BALB-C MICE
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 1
Abstract
The gastrointestinal tract is responsible for the absorption of nutrients and water into the body as well as the elimination of body waste. The small intestine is comprised of a long convoluted tube that is divided into the duodenum, jejunum, and ileum. Its functions consist of absorption of nutrients and water as well as retention and passage of waste materials. The movement of intestinal contents is dependent on the contraction of muscle fibers that are located throughout the intestinal wall. Absorption and movement of the contents are brought about by the activities of the absorptive cells of the mucosa and by coordinated contraction of the smooth muscle cells of the muscularis externa. The movements of the gut involve simultaneous contractions and relaxations of both circular and longitudinal smooth muscle layers at every point along its length. Mechanical recordings of physiological events can be traced back to the kymographic method. Keeping the above findings in view, the present study aims at understanding, whether already established dose of fenoterol, known to induce atrophic changes in muscles is likely to induce any toxic effects on other organ of vital importance or not. Hence, the experiment is designed in such a way to examine the undesirable toxic effects on smooth muscles.
Authors and Affiliations
Pooja Sharma , Sushma Sharma
Keywords
Related Articles
- EP ID EP131991
- DOI -
- Views 99
- Downloads 0
RAPID POLYMERASE CHAIN REACTION METHOD FOR DETECTION OF VIBRIO CHOLERAE IN FOOD AND THEIR CYTOTOXIC EFFECT
In the present study, the rapid detection of Vibrio cholerae in food and cytotoxic activity, food samples were collected. Twelve food samples were analyzed for the incidence of Vibrio cholera. The organism isolat...
SOLUBILITY AND DISSOLUTION ENHANCEMENT OF ACECLOFENAC BY SOLID DISPERSION TECHNIQUE
ABSTRACT Aceclofenac an analgesic and anti-inflammatory drug used intreatment of Osteo arthritis, rheumatoid arthritis and ankylosing spondylitis.Aceclofenac solid dispersions were prepared using hydrophillic pol...
DESIGN AND IN VIVO EVALUATION OF GASTROINTESTINAL MUCOADHESIVE PATCH SYSTEM (GMPS) LOADED WITH CHITOSAN NANOPARTICLES
ABSTRACT A novel gastrointestinal mucoadhesive patch system was designed to improve the oral bioavailability of macromolecular therapeutics using chitosan nanoparticles for effective delivery of macromolecules (u...
A REVIEW ON DENTAL PLAQUE
ABSTRACT Dental plaque is a biofilm usually a pale yellow colored that develops naturally on the teeth. Dental plaque is a cluster of colonized bacterial growth which attaches itself to the tooth structure. Plaqu...
IN-VITRO ANTI INFLAMMATORY ACTIVITY OF ULTRA SONIC BATH ASSISTED, METHANOL EXTRACT OF LEPIDIUM SATIVUM LINN. SEEDS
Plants can provide biologically active molecules and lead structures for the development of modified derivatives with enhanced activity and reduced toxicity. There are certain problems associated with use of anim...