FORMULATION AND INVITRO EVALUATION OF FAMOTIDINE FLOATING TABLETS
Journal Title: International Journal of Pharmaceutical Development & Technology - Year 2014, Vol 4, Issue 4
Abstract
ABSTRACT The objective of the present study was to prepare and evaluate gastroretentive floating drug delivery system containing Famotidine as a model drug. Famotidine tablets were prepared by wet granulation method using Hydroxypropylmethyl celluloseHPMC E5 LV by effervescent technique. Sodium bicarbonate (SB) and citric acid (CA) were incorporated as gas-generating agents. Floating tablets were evaluated for uniformity of weight, thickness, hardness, friability, drug content, in vitro buoyancy and dissolution studies. The effect of effervescent agent on drug release profile and floating properties was also investigated. Prepared tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non– Fickian diffusion was confirmed as the drug release mechanism from these tablets, indicating that water diffusion and polymer rearrangement played an essential role in drug release. All the prepared tablets showed good in vitro buoyancy. Keywords: Famotidine, Floating tablets, HPMC, In vitro buoyancy, Controlled release.
Authors and Affiliations
Aparna C*, Umasankar K, Jayachandra Reddy P, Prabhakaran V, Venkatesh E
Keywords
Related Articles
- EP ID EP128353
- DOI -
- Views 114
- Downloads 0
PULSATILE DRUG DELIVERY SYSTEM: AN OVERVIEW
Current research in the field of drug delivery devices, pulsatile drug delivery system is the most interesting time and site-specific system. This system is designed for chronopharmacotherapy. Thus, to mimic the fu...
TOXICOLOGICAL EVALUATION OF NEERZHIVU CHOORNAM-A SIDDHA ANTI-DIABETIC POLYHERBAL FORMULATION
ABSTRACT Herbal formulations are getting popularity throughout the world and commercialized extensively for various medicinal properties. WHO has emphasized the need for quality assurance of herbal products, incl...
FORMULATION AND IN-VITRO CHARACTERIZATION OF FLOATING MICROCARRIERS OF VENLAFAXINE HYDROCHLORIDE
The objective of the present study was to develop multiparticulate gastro retentive drug delivery system of Venlafaxine hydrochloride by Emulsion gelation method using sodium alginate as a polymer and liquid para...
FORMULATION AND EVALUATION OF BILAYER FLOATING TABLET CONTAINING VERAPAMIL HYDROCHLORIDE
The objective of the present investigation was to develop a bilayer-floating tablet (BFT) for Verapamil Hydrochloride using direct compression technology using floating and viscosity enhancing polymers such as HP...
FENOTEROL BETA- AGONIST ON CONTRACTION AND RELAXATION OF INTESTINAL SMOOTH MUSCLE OF MALE ALBINO BALB-C MICE
The gastrointestinal tract is responsible for the absorption of nutrients and water into the body as well as the elimination of body waste. The small intestine is comprised of a long convoluted tube that is divid...