Microbial spoilage, instability risk of antacid suspension in the presence of commonly used preservative system
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 5
Abstract
Manifestation of microbial spoilage of any product by bacteria and to assess the effectiveness of the anti-microbial preservatives (parabens) used for the prevention and stability purpose. The aim of the present work is to study the effectiveness of preservatives used in the antacid suspensions and to analyze the effect of microbial growth on the quality of respective antacid suspensions. Samples of various antacid suspensions were randomly collected from local market and Government hospital pharmacies. Three different antacid formulations were prepared in the laboratory. All the formulations were preliminarily evaluated on the basis of organoleptic characteristics, pH, viscosity and assay. Efficacy of the preservative system in suspension formulation was determined by inoculating the samples in its final container, with specific strains of bacteria i.e. Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 9027 and Staphylococcus aureus ATCC 6538, taking samples from the inoculated preparation at specified intervals of time i.e. 0 time, 07 days, 14 days and 28 days, growing it on nutrient agar medium and colony forming units (CFUs) were scored by plate count. At the same time the samples were also subjected to qualitative and quantitative testing. The decrease in CFU and alteration in assay, pH and viscosity was observed in all the formulations except formulation M2 and F3 that showed stability throughout the study period.
Authors and Affiliations
Jamshaid Ali Khan , Imran Ullah Khan , Zafar Iqbal , Fazli Nasir , Salar Muhammad , Peer Abdul Hannan , Irfan Ullah
Keywords
Related Articles
- EP ID EP111607
- DOI -
- Views 127
- Downloads 0
Molecular docking studies of withanolides against Cox-2 enzyme
Withaniasomnifera (Ashwaganda) belonging to the family solanaceae is the subject of our present study. Withanoloides which are the major chemical constituents have been proved of interest because of their structural vari...
The effects of new polyherbal Unani formulation AJMAL06 on serum creatinine level in chronic renal failure
This study was conducted to evaluate the efficacy of Unani Ajmal06, an herbal formulation for management of chronic renal failure (CRF). The therapeutic evaluations of three different formulations such as Itrifal K...
Identification of Sulfamoylbenzamide derivatives as selective Cathepsin D inhibitors
Aspartic proteases play very important role in post translational processing of proteins and several of them are essential for organism’s viability. Here we present the enzyme inhibition activities of different Sulfamoyl...
Phytochemical analysis, antimicrobial, antioxidant activities and total phenols of Ferulago carduchorum in two vegetative stages (flower and fruit)
Ferulago carduchorum (Apiaceae family) is an endemic plant of Iran. The crude extract and four fractions of aerial parts of F. carduchorum in two vegetative stages (flower and fruit) were studied for their total ph...
Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus
The ethanolic root extract of C. zambesicus (27-81mg/kg) was evaluated for antiiflammatory, analgesic and antipyretic properties in mice. The extract (27-81mg/kg) demonstrated a weak antiinflammatory activity. However, a...