ONE-POT MULTI-COMPONENT SYNTHESIS OF FULLY SUBSTITUTED PYRAZOLES DERIVATIVES IN BIOCOMPATIBLE DEEP EUTECTIC SOLVENTS
Journal Title: Asian J of Pharm Sci & Tech - Year 2015, Vol 5, Issue 3
Abstract
ABSTRACT An efficient protocol for the synthesis of fully substituted pyrazoles in deep eutectic solvents under solvent-free conditions is reported here. The reaction is remarkably facile because of the air and water stability of the catalyst, and needs no special precautions. The reactions were completed within 1hr with excellent yields .The products formed were sufficiently pure, and can be easily recovered. The use of ionic liquid choline chloride/urea in solid phase offered several significant advantages such as low cost, greater selectivity and easy isolation of products. Key words: Green chemistry, One-pot synthesis, Pyrazoles, Deep Eutectic Solvents (Des).
Authors and Affiliations
Santosh Bansilal Katariya*
Keywords
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