Normogonadotropic ovarian insufficiency in adolescence (review of literature and clinical case)
Journal Title: Міжнародний ендокринологічний журнал - Year 2017, Vol 13, Issue 5
Abstract
The objective of the review. Analysis of literature data related to the normogonadotropic ovarian insufficiency. Basic statements. The article presents a literature review and clinical case of normogonadotropic ovarian insufficiency in girls aged 16 years. The basic clinical-laboratory and genetic criteria are distinguished. We searched for published and unpublished studies using Pubmed as the search engine by the keywords: “normogonadotropic ovarian insufficiency”, “aromatase”, “molecular diagnosis”, “polycystic ovary syndrome”, “adolescents”, “clinical cases”, taking into consideration researches conducted for the last 15 years, citation review of relevant primary and review articles, conference abstracts, personal files, and contact with expert informants. The criterion for the selection of articles for the study was based on their close relevance to the topic, thus out of 256 analysed articles, the findings of the researchers covered in 34 articles were crucial. Because several features of polycystic ovary syndrome may be in evolution in adolescents, we suggest that only firm criteria should be used to make a diagnosis in adolescence: hyperandrogenism, oligomenorrhea and ovarian morphology. The most frequent clinical manifestations of aromatase deficiency of ovarian follicles are opsomenorrhea and androgen-dependent dermatopathy аnd genotype CYP19 ((TTTA)n polymorphism) — (TTTA)7(TTTA).
Authors and Affiliations
T. V. Sorokman, S. V. Sokolnyk, P. M. Moldovan,, N. O. Popeliuk
Keywords
Related Articles
- EP ID EP240173
- DOI 10.22141/2224-0721.13.5.2017.110027
- Views 77
- Downloads 0
Association of Certain Endothelial Function Indicators with T894G Polymorphism of Endothelial Nitric Oxide Synthase Gene in Patients with Hypothyroidism and Concomitant Chronic Cholecystitis
The association of the T894G endothelial nitric oxide synthase (eNOS) gene polymorphism with certain indicators of endothelial function in patients with hypothyroidism and concomitant chronic non-calculous cholecystitis...
Efficiency of D2 Receptors Agonists in treatment of Patients with Non-Functional Pituitary Adenoma with Hereditary-Tainted Anamnesis
There were analyzed two clinical cases of non-functional pituitary adenoma with the hereditary-tainted anamnesis. The presence of the original disposition or familial-hereditary cases of non-functional pituitary adenoma...
Thyrostatic Drugs in the Treatment of Diffuse Toxic Goiter
.
Siofor Efficacy in Treatment of Patients with Obesity and Hyperinsulinism on the Prediabetes Stage
The efficacy of Siofor for patients with constitutional and diet-induced obesity and hyperinsulinism has been analyzed. This medication in effective dose was found to have positive effect on lipid and carbohydrate metabo...
Endogenous Peptide Apelin and Pathological Cardiac Remodeling in Hypertensive Patients with Diabetes Mellitus Type 2
The study involved 63 patients with essential hypertension and diabetes mellitus type 2. The control group consisted of 16 apparently healthy individuals. Complex of examination included conventional clinical-laboratory...