ONE-POT SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF 2-AMINO-5-ARYL-5H-THIAZOLO [4,3-b]-1,3,4-THIADIAZOLES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 1
Abstract
A series of 2-amino-5-aryl-5H-thiazolo[4,3-b]-l,3,4-thiadiazoles were synthesized by using aromatic aldehydes, thioglycolic acid and thiosemicarbazide. Equimolar mixtures of aromatic aldehydes with thioglycolic acid and thiosemicarbazide in H2SO4 transform into 2-amino-5-aryl-5H-thiazolo[4,3-b]-l,3,4-thiadiazoles. Structures of all synthesized compounds were confirmed by FTIR, 1H NMR and mass spectral data. Their antitubercular activity has been studied. All the synthesized compounds have shown good antitubercular activity.
Authors and Affiliations
Asif A. Karigar , M. Himaja , Sunil V. Mali , K. Jagadeesh Prathap, Mukesh S Sikarwar
Keywords
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