Pathogenic and Industrial Implications of Lipase Enzyme Extracted from Aspergillus niger: A Comparative Study of Biotechnological Applications and Clinical Risks
Journal Title: Falcons Journal of Advanced Research - Year 2025, Vol 1, Issue 2
Abstract
Aspergillus niger is a widely distributed filamentous fungus known for its significant role in industrial biotechnology and its potential as an opportunistic pathogen. This study investigated the production, characterization, and industrial applications of A. niger-derived lipase while assessing its pathogenic risks and biosafety concerns. Lipase production was optimized using solid-state fermentation (SSF) and submerged fermentation (SmF) techniques, with results indicating maximum enzyme activity at pH 7.5 and 40°C. The enzyme demonstrated strong substrate specificity, particularly for long-chain triglycerides, making it highly suitable for detergents, pharmaceuticals, and food industries. Comparative analysis with bacterial and yeast-derived lipases revealed that A. niger lipase offers high substrate specificity and cost-effective production, but has moderate thermostability compared to bacterial lipases. The study also reviewed clinical cases of A. niger-related infections, particularly otomycosis, onychomycosis, and pulmonary aspergillosis, highlighting its impact on immunocompromised individuals. Antifungal resistance patterns and biosafety concerns, particularly mycotoxin contamination, were assessed, emphasizing the need for regulatory measures in large-scale enzyme production. Despite its pathogenic potential, GRAS-certified A. niger strains remain a reliable source of industrial enzymes, provided that strict quality control and safety protocols are followed. This research contributes to the ongoing biotechnological advancements in enzyme production while addressing the clinical and regulatory challenges associated with A. niger. Future studies should focus on genetic modifications, enzyme immobilization techniques, and sustainable fermentation strategies to enhance the stability, efficiency, and biosafety of A. niger-derived lipases.
Authors and Affiliations
Aimen Chaudhry, Sadia Sajjad, Qurat Ul Ain, Ramisha Kamran, Iqra Chaudhary
Keywords
Related Articles
- EP ID EP763095
- DOI 10.63287/609256
- Views 47
- Downloads 1
The Personality of Allama Iqbal in the Light of His Letters (علامہ اقبال کی شخصیت ان کے خطوط کی روشنی میں)
The personality of Allama Muhammad Iqbal (1877–1938) is a blend of profound intellectual, spiritual, and practical dimensions, as reflected in his letters. While his poetry and philosophical ideas are celebrated worldwid...
Enzyme-Based Bioremediation and Its Clinical Overlap: Potential Risks of Aspergillus-Derived Biocatalysts
The rise in industrial and environmental applications of microbial enzymes has brought renewed attention to the dual potential and peril posed by fungal species like Aspergillus niger. This study investigates the bioreme...
Pathogenic and Industrial Implications of Lipase Enzyme Extracted from Aspergillus niger: A Comparative Study of Biotechnological Applications and Clinical Risks
Aspergillus niger is a widely distributed filamentous fungus known for its significant role in industrial biotechnology and its potential as an opportunistic pathogen. This study investigated the production, characteriza...
Memory, Trauma, and the Death Drive: A Psychoanalytic Perspective on Never Let Me Go
This study applies psychoanalytic theory to Kazuo Ishiguro's novel "Never Let Me Go," focusing on the themes of memory, trauma, and the death drive. By examining the inner lives of the novel's cloned characters—Kathy, To...
The Evolution of Leadership Styles in the Era of Hybrid Work Models
The emergence of hybrid work models has redefined workplace dynamics, requiring leaders to adapt their traditional approaches to effectively manage dispersed teams. This research examines the evolution of leadership styl...