Phytochemical investigation & evaluation for antidiabetic activity of leafy extracts of various Ocimum (Tulsi) species by alloxan induced diabetic model
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 1
Abstract
The various species of Ocimum (Lamiaceae) i.e. Ocimum gratissimum linn., Ocimum americanum linn., Ocimum sanctum linn. and Ocimum basilicum linn. are widely distributed in tribal areas of south eastern Odisha and extensively used traditionally by the tribal people for common colds, headaches, stomach disorders, inflammation, heart diseases, antidiabetic, treatment of various forms of poisoning, malaria and as anthelmintic. The present study is an attempt to preliminary investigation of phytochemical constituents and to explore the antidiabetic activity of methanolic extracts of leaves of various Ocimum species including the comparison of their activity. The Ocimum extracts were screened for phytochemical constituents and evaluated for their antidiabetic activities by alloxan induced diabetic model in Wister rats. All the tests for phytochemical constituents of methanolic extract of Ocimum species were found to be positive except anthraquinone glycosides and thiol group. All extracts were able to show antidiabetic activity at 0.5 mg/Kg concentration. The activities are well comparable with the standard drug, glibenclamide. The methanolic extract of Ocimum sanctum linn showed better antidiabetic activity in comparison with other species of Ocimum and standard drug. The data were verified as statistically significant by using one way ANOVA at 5 % level of significance (p < 0.05).
Authors and Affiliations
Choudhury Golak Bihari*, Behera Manaswini, Panda Sangram Keshari and Tripathy Sujit Kumar
Keywords
Related Articles
- EP ID EP85746
- DOI -
- Views 180
- Downloads 0
Determination of LD50 and ED50 by dose response relationship and assessment of toxicological and non toxicological behaviour of Ipomoea hederacea
The present study was designed to evaluate the toxic and non toxic profile of Ipomoea hederacea (Convolvulaceae). The results of oral toxicity study was observed in mice at the doses of 300, 200, 100, 50, 25, 10, 1, 0.0...
Antifungal Activity and Phytochemical Analysis of Aqueous Extracts of Ricinus communis and Punica granatum
In the present investigation, the aqueous leaf and pericarp extracts of castor oil plant (Ricinus communis) and pomegranate (Punica granatum) were evaluated for antifungal activity against Candida species and subsequentl...
Evaluation of anti-inflammatory activity of the leaf extract of Wrightia tomentosa. Roem & Schult
The methanol: dichloromethane (1:1) extract of the leaves of Wrightia tomentosa (Family: Apocynaceae), a traditional medicine plant was tested for anti-inflammatory activity dextran induced paw edema in rats. The results...
Management of hypertension in pregnancy: A review
Hypertension in pregnancy is the most common cause of maternal death, with a risk of approximately 10 deaths / million pregnancies in the UK. Hypertension in pregnancy is also the most common cause of stillbirth and neon...
Screening and pharmacophore studies of indian plant anticancer compounds database against H-RAS P21 protein inhibitors using molecular docking
Many intracellular proteins are post-translationally modified by the attachment of lipid through the process called farnesylation, which plays an important role in the signal transduction pathway that leads to constant...