Phytochemical Screening and Metallic Ion Content and Its Impact on the Antipsoriasis Activity of Aqueous Leaf Extracts of Calendula officinalis and Phlebodium decumanum in an Animal Experiment Model
Journal Title: Turkish Journal of Pharmaceutical Sciences - Year 2019, Vol 16, Issue 3
Abstract
Objectives: The aim of this study was to evaluate the influence of metal ions present in soil as well as in leaf samples of Calendula officinalis and Phlebodium decumanum for the treatment of psoriasis. Materials and Methods: To meet the objective, soil and leaf samples were estimated for metal ions by atomic absorption spectrophotometer to determine the influence in antipsoriatic activity. Thereafter imiquimod-induced dermatitis lesions were created in grouped mice. Two plant extracts (aqueous) separately as well as in combinations and standard Retino-A (0.05%) were used. Psoriasis severity index (PSI) was evaluated according to the phenotypic (redness, erythema, and scales) and histological features (epidermal thickness). Further content of phytochemicals in terms of extract was correlated with the effect of psoriasis activity. Results: We observed redness, erythema, and scales and the histological features and found a progressive reduction (P<0.05) in the severity of psoriatic lesions (redness, erythema, and scales) from days 7 to 21 and decreased epidermal thickness in animals treated with combined extracts at a dose of 200 mg/kg b.w. Furthermore, plant samples procured from the Nandi Hills, Bangalore, showed better uptake of metals with respect to Fe (2.05 mg/kg), Cu (0.78 mg/kg), and Zn (1.12 mg/kg), which showed a positive impact on procurement of maximum amount of extracts that further correlated with the activity, indicating a significant reduction in psoriatic lesions. Conclusion: The results revealed that the significant dose-dependent antipsoriasis activity of combined aqueous extracts of C. officinalis and P. decumanum as well as metal ions had an impact on the procurement of extracts and said activity.
Authors and Affiliations
Kuntal DAS, Someswar DEB, Tejaswini KARANTH
Keywords
Related Articles
- EP ID EP48825
- DOI 10.4274/tjps.galenos.2018.44265
- Views 346
- Downloads 0
Identification, Quantification, and Antioxidant Activity of Hydroalcoholic Extract of Artemisia campestris from Algeria
Objectives: Our study aimed to investigate the chemical profile of hydroalcoholic extract of Algerian Artemisia campestris and its antioxidant activity. Materials and Methods: The hydroalcoholic extract of Algerian A. c...
In Vitro Caco-2 Cell Permeability Studies of Ziprasidone Hydrochloride Monohydrate Nanocrystals
Objectives: The current study focused on the evaluation of the cytotoxic effect and permeability of ziprasidone hydrochloride monohydrate (ZHM) nanocrystals on Caco-2 cells. Materials and Methods: ZHM nanocrystals were...
Comparison of the Essential Oils of Ferula orientalis L., Ferulago sandrasica Peşmen and Quézel, and Hippomarathrum microcarpum Petrov and Their Antimicrobial Activity
Objectives: To determine the chemical composition and antimicrobial activity of the essential oils of the aerial parts of Ferula orientalis L., roots of Ferulago sandrasica Peşmen and Quézel, and aerial parts of Hippomar...
Theoretical Study on Ionization of Boric Acid in Aqueous Solution by Ab Initio and DFT Methods at T=298.15 K
Objectives: The aim of this research work was to theoretically calculate the pKa value of boric acid in aqueous solution by theoretical methods at T=298.15 K. Materials and Methods: Boric acid has antifungal and antivir...
Ethnopharmacological Knowledge for Management of Oral Mucositis in Zahedan, Southeast Iran
Objectives: Oral mucositis is among the complications of cancer therapy that affects quality of life and imposes remarkable financial costs for patients with cancer. This study aimed to explore, preserve, and scientifica...