Platelet indices in diabetics and influence of glycemic control – a hospital based study in North-East India
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 12
Abstract
Introduction: Platelets from patients with type 1 and type 2 diabetes exhibit enhanced platelet aggregation activity early in the disease course that may precede the development of cardiovascular diseases. Both atherosclerosis and thrombosis appear to contribute significantly to the increased cardiovascular risk of diabetic patients. Platelet indices include mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR). This study was undertaken with the aim to find out the differences in platelet indices between diabetics and non-diabetics and also between patients with controlled and uncontrolled diabetes mellitus in a tertiary health care centre in North East India. Methods: This is a cross sectional study conducted in Agartala Government Medical College and GB Pant Hospital (AGMC & GBP Hospital). 100 cases and 100 controls were selected from the Diabetes clinic of Medicine out patient department (OPD) and Medicine wards. Platelet indices and HbA1C levels of these cases and controls were measured. Platelet indices were measured by a 3-part differential hematology auto-analyzer and HbA1C by High Performance Liquid Chromatography (HPLC) method. Blood glucose levels were estimated by oxidase-peroxidase method. Results: Platelet indices were found to be significantly higher among diabetics compared to non-diabetics and also they were found higher among patients with poor glycemic control with HbA1C>7% in comparison to patients with good glycemic control with HbA1C<7% (P value <0.05). Conclusions: Platelet indices are significantly increased in diabetics and the extent of increment is more in diabetics with poor glycemic control.
Authors and Affiliations
Prasun Bhattacharjee, Abhijit Datta, Rajesh Kishore Debbarma, Swapan Kumar Das
Keywords
Related Articles
- EP ID EP231800
- DOI 10.17511
- Views 141
- Downloads 0
Correlation of preoperative co-morbidities with post-operative outcomes in patients operated for hip fractures
Introduction: As the population ages, disability and death is becoming more common in which hip fracture is one of the commonest cause. The purpose of this study is to analyse the effect of preoperative co-morbidities on...
The current role of imaging in the prenatal diagnosis of fetal achon-droplasia: medical management and dental implications
We present the case of a patient with the following diagnosis: 29 weeks pregnancy in evolution, fetal achondroplasia with orofacial manifestations: macrocephaly, domed forehead, depressed nasal bridge, maxillary hypoplas...
Chemo-radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck with or without Lapatinib – a non randomised comparison study to assess the tolerance and efficacy
Purpose of the study: We intend to test the efficacy of and toxicity of addition of Lapatinib to the standard of care in locally advanced squamous cell carcinoma of the head and neck (LAHNSCC). Materials/Methods: Between...
A clinico hematological correlation of autoimmune hemolytic anemia and its clinical implication
Introduction: Autoimmune hemolytic anemia characterized by production of antibodies that attach to Red cells resulting in their destruction causing anemia. AIHA could be primary or secondary to some other cause. The posi...
Nondescent vaginal hysterectomy, a changing practice in Indian scenario for scar less surgery
Introduction: Hysterectomy is the most common operation performed next only to caesarean operation by gynaecologist. This decade has seen resurgence of hysterectomy by vaginal route for indication other than prolapse, ma...