Potassium Bromate Induced Renal Toxicity in Wistar Albino Rats: Effects of Aqueous Extract of Nutmeg (Myristica fragrans Houtt)
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 5, Issue 12
Abstract
Much attention has been drawn to the toxic effect of bromate on the organs like liver, spleen etc. However, it is not clear whether or not the toxicity of bromate is related to other vital organs like the kidney. Hence, the present work is geared towards not only unraveling the toxic effect of bromate on the kidney but more importantly investigate the protective effect of African nutmeg Myristica fragrans against bromate induced toxicity in this organ. Twenty wistar albino rats (180 to 200 g) were divided into 4 groups. Group I was given normal rat feed with water as control; group II was administered with 1.0mL Potassium bromate (KBrO3) solution (30 mg/kg body weight); groups III and IV were simultaneously administered with 1.0mL of KBrO3 each and 1.0mL of 20% and 40% aqueous extract of African nutmeg respectively. All the treatments were given daily for two weeks. Enzyme biomarkers such as Aspartate Transaminase (AST), Alkaline Transaminase (ALT), Alkaline Phosphatase (ALP), Superoxide Dismutase (SOD), Catalase (CAT), reduced glutathione (GSH), Cholesterol (CHOL), High Density Lipoprotein-Cholesterol (HDL-CHOL), Triglycerides (TRIG), and Malondialdehyde (MDA) were measured in the kidney homogenate. Results obtained showed that although bromate exerted significant (P < 0.05) toxic effects on the kidney homogenate, administration of the aqueous seed extract of African nutmeg caused a marked reversal in the toxicity of bromate in a dose dependent fashion. Since, the introduction of bromate caused an alteration in enzyme biomarkers in the kidney homogenate, this indicates that the seed is a potential antioxidant against bromate toxicity of the kidney tissues.
Authors and Affiliations
O. A. Oseni, S. A. Olagboye, A. S. K. Idowu
Keywords
Related Articles
- EP ID EP347059
- DOI 10.9734/BJMMR/2015/10008
- Views 66
- Downloads 0
Tight Hamstring Syndrome Related Lumbar Disc Herniation and Its Rehabilitation Program to Two Case Reports
Tight hamstring syndrome (THS) is a symptom complex which has a varied pathogenesis. The syndrome usually occurs in childhood and adolescent period. It is characterized by tightness of lumbar, ischial and crural muscles....
A Systematic Encounter with a Psycho-oncologist: Longitudinal Study in Women with Breast Cancer
Introduction: Cancer patients usually will not ask for psychological support. To increase the proportion of patients who may benefit from psychological support, an encounter was implemented in our hospital, within days f...
Cardiopulmonary Changes after Dental Procedures with Adrenaline Containing Local Dental Anesthesia
Background: The injection of adrenaline containing local dental anaesthesia may be associated with variable adverse effects on the cardio- respiratory system that are clinically undetectable. Methods: The p...
Primary Lip Leishmaniasis-Report of 4 Cases from a Non-endemic Region of Kashmir Valley of North India and Review of Literature
Leishmaniasis is a disease caused by an intracellular protozoan parasite of the genus Leishmania and transmitted by the bite of a female sandfly(phlebotomus). The clinical spectrum of leishmaniasis ranges from a self-res...
Health Maintenance Organization-Federally Qualified Health Center (HMO-FQHC) Collaboration to Provide After-Hours Pediatric Primary Care: A Feasibility Study
Aims: Examine feasibility, implementation and impact of a Health Maintenance Organization (HMO)-Federally Qualified Health Center (FQHC) collaboration in providing after-hours care as an Emergency Department (ED) diversi...