Progress in the development of CRISPR genome editing technology and its application in ophthalmic disease
Journal Title: Eye Science (Yanke Xuebao) - Year 2021, Vol 36, Issue 7
Abstract
Clustered regularly interspaced short palindromic repeats (CRISPR) genome editing is a newly developed technology to precisely modify cellular DNA sequence, which could control cell fate and phenotype and fundamentally reform disease treatment. The structure of the eye offers unique advantages as a genome editing target. Recently, a CRISPR genome editing therapy has begun to be tested in Leber congenital amaurosis 10(LCA10) patients, and the clinical trials for more ocular diseases are about to start. The development of CRISPR/Cas genome editing tools will drive major advances in the application of gene therapies in the treatment of ophthalmic disease.
Authors and Affiliations
Danbao MA, Weiye ZHONG, Chen YU
Keywords
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- EP ID EP763538
- DOI 10.3978/j.issn.1000-4432.2021.06.19
- Views 15
- Downloads 0
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