Protective effect of Brazilian propolis ethanol extract against stress-induced gastric mucosal lesions in rats. Its evaluation using oxidative stress markers
Journal Title: Journal of Analytical Bio-Science - Year 2011, Vol 34, Issue 2
Abstract
We evaluated the protective effect of Brazilian propolis ethanol extract (BPEE) against gastric mucosal lesions in rats with water-immersion restraint stress (WIRS) using oxidative stress markers. Exposure of Wistar rats to 6 h of WIRS caused lesion development, increased lipid peroxide (LPO) and NOx concentrations and xanthine oxidase and myeloperoxidase activities, and decreased non-protein SH, ascorbic acid, and vitamin E concentrations in the gastric mucosa. Pre-administration of BPEE (10, 50 or 100 mg/kg, p.o.) prevented the lesion development by the following order: 50 mg/kg > 100 mg/kg > 10 mg/kg. Each dose of BPEE attenuated the increased xanthine oxidase activity and the decreased non-protein SH concentration. BPEE (50 mg/kg) attenuated the increased LPO and NOx concentrations and the decreased ascorbic acid and vitamin E concentrations. BPEE (100 mg/kg) attenuated the increased LPO concentration. These results suggest that BPEE protects against WIRS-induced gastric mucosal lesions in rats through its antioxidant properties.
Authors and Affiliations
Tadashi Nakamura, Yoshiji Ohta, Koji Ohashi
Keywords
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