Protein Modeling and Sequence Analysis Studies on Human Lung Cancer Potential Protein Target (Crp C-Reactive Protein, Pentraxin-Related) Using Bioinformatics Protocols
Journal Title: International Journal of Novel Trends in Pharmaceutical Sciences - Year 2012, Vol 2, Issue 4
Abstract
Lung cancer is the second most commonly occurring form of cancer in most Western countries, and it is the leading cancer-related cause of death. In contrast to the mortality rate in men, which began declining more than 20 years ago, women's lung cancer mortality rates have been rising over the last decades, and are just recently beginning to stabilize. The evolution of "Big Tobacco" plays a significant role in the smoking culture. In this research study we found out the potential mutation gene involved in Human Lung cancer disease and to perform protein sequence analysis, protein modelling and ligand binding sites prediction using Bioinformatics tools. There are three steps involved in our present research investigation. The protein primary structure analysis, protein three dimensional structure prediction and drug binding sites identification. The identified drug binding sites of the (CRP C- REACTIVEPROTEIN, PENTRAXIN-RELATED) protein are the best potential inhibitors for drug docking studies. The identification of drug (ligand) binding sites is an important step in insilico structure based drug designing and `in the field of cheminformatics. The targets discovered by us would certainly prove to be useful in treating Lung cancer disease in Human beings.
Authors and Affiliations
Vasiya thanveer , M Balaji
Keywords
Related Articles
- EP ID EP87618
- DOI -
- Views 108
- Downloads 0
Three - Dimensional Structure Prediction and Drug Binding Studies on Mutated Gene (CHRNA5) In Human Lung Cancer Disease
Worldwide, lung cancer is the most common cancer in terms of both incidence and mortality. In 2008, there were 1.61 million new cases, and 1.38 million deaths due to lung cancer. The highest rates are in Europe and North...
Synthesis and characterization of carboxymethyl cellulose/ polyethylene glycol/montmorillonite clay blends
The present study deals with the synthesis and characterization of the ternary blends of carboxymethyl cellulose, polyethylene glycol and montmorillonite clay of ratio 1:1:1 in the presence and the absence of the crossli...
A Focus on Quinolones and its Medicinal Importance
Quinolones are a very important family of antibacterial agents that are widely prescribed for the treatment of infections in humans. Quinolones comprise a relatively large, growing and most interesting group of antibacte...
Drug designing and validation studies on human asthma disease gene NPSR1 using Cheminformatics tools
Asthma is defined by the Global Initiative for Asthma as a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. The chronic inflammation is associated with airway hyper resp...
Design and RP - HPLC Method for the Simultaneous determination of Valsartan and Hydrochlorothiazide in Bulk and in Pharmaceutical Formulation
A reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of valsartan and hydrochlorothiazide in bulk and in pharmaceutical formulation using RP - C18 column. The...