Rare Oral Mucosal Manifestations of Hydroxyurea Therapy in Chronic Myeloid Leukemia
Journal Title: Haematology International Journal - Year 2017, Vol 1, Issue 2
Abstract
Chronic myeloid leukemia (CML), is myeloproliferative neoplasm, that accounts for 15-20% of all leukemia’s in adults, resulting from reciprocal translocation between the long arms of chromosomes 9 and 22(Philadelphia chromosome), producing BCR-ABL oncogene fusion, which is currently targeted by tyrosine kinase inhibiters (TKIs), but still Hydroxyurea (HU) usedin chronic myeloid leukemia, its role as cytoreduction and as bridging therapy before starting tyrosine kinase inhibitors (TKI). There are several recognized side effects of hydroxyurea, such as cutaneous abnormalities and here we report rare mucous manifestations of hydroxyurea.
Authors and Affiliations
Mohamed A Yassin
Keywords
Related Articles
- EP ID EP291038
- DOI -
- Views 128
- Downloads 0
Lymphoma without Peripheral Lymphadenopathy: An Approach to Definitive Diagnosis by Flowcytometry
Splenic lymphoma with circulating villous lymphocytes (SLVL) is an indolent B-cell neoplasm. Because of its rarity, a definitive diagnosis often becomes difficult. In this study we are going to discuss about two cases of...
Hypoarginaemia among Pre- School Children of African Descent with Plasmodium Falciparum Malaria
Malaria is a public health problem particularly in the tropical areas of the world affecting about 247 million people each year and often resulting in nearly a million deaths. It is the leading cause of under-five hospit...
A Unique Case of Primary Hepatic CD30-Positive, CD15-Negative Classical Hodgkin’s Lymphoma Presenting as Fever of Unknown Origin and Acute Hepatic Failure
Hodgkin’s lymphoma is a B-cell lymphoproliferative neoplasm that commonly presents with lymphadenopathy and constitutional symptoms. Primary Hodgkin’s lymphoma of the liver without extrahepatic lymphadenopathy is rare, r...
Environmental Factors as Determinants of Severity of SCD in Nigeria
Sickle cell anaemia (SCA) is a chronic blood disorder characterized by red blood cells that assume an abnormal sickle shape when deoxygenated and may block different areas of the microcirculation causing ischaemia in var...
Resolving Serological Blood Group Discrepancy and Providing Transfusion Support in a Patient of Mixed Auto Immune Hemolytic Anemia: A Case Report
ABO grouping should include both forward and reverse grouping procedure, and results of two procedures should agree with each other. Mixed autoimmune hemolytic anemia (AIHA) is defined as presence of both warm and cold a...