Relationship between polyamines and polyamine metabolism with malignant tumors
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 6
Abstract
Polyamines such as spermine, spermidine, and putrescine play pivotal roles in the proliferation, differentiation, and development of eukaryotes. Multiple regulatory mechanisms strictly control intracellular polyamine concentrations to maintain them within specific physiological ranges in normal cells. However, abnormal expression of enzymes in the metabolic pathways of polyamines, found in many tumor states such as cancer, results in the dysregulation of polyamines. Targeting key enzymes in the polyamine metabolic process is considered a potential therapeutic strategy, as polyamines are involved in regulating anti-tumor immune responses. Research has shown that dysregulation of polyamine metabolism is critical in cancer development and progression. In this paper, recent advancements in polyamine research will be systematically discussed, including their metabolic pathways in cancer research.
Authors and Affiliations
TANG Xupeng, LIANG Lu, ZHANG Li, SHEN Juanning, LI Ning
Keywords
Related Articles
- EP ID EP738678
- DOI 10.13429/j.cnki.cjcr.2024.06.029
- Views 42
- Downloads 0
20240508
<b>Objective</b> Based on the clinical study of patients infected after percutaneous vertebral augmentation procedures (PVAP), the infection related factors and clinical characteristics were analyzed to provide basis for...
Effects of esketamine combined with thoracic paravertebral block on postoperative early sleep in patients undergoing thoracoscopic lobectomy
Objective To observe the effects of continuous intravenous infusion of esketamine combined with thoracic paravertebral nerve block (TPVB) on postoperative early sleep, analgesia, and recovery quality in patients undergoi...
Relationship between puerarin and urothelial carcinoembryonic antigen 1 expression in apoptosis and autophagy of esophageal cancer cells
"<b>Objective</b> To explore the molecular mechanism of puerarin on apoptosis and autophagy in esophageal cancer cells. <b>Methods</b> Human esophageal cancer EC109 cells were treated with puerarin at 0, 200, 500, 800...
Risk factors and predictive efficacy of anastomotic fistula after radical right hemicolectomy
Objective To explore the risk factors for the occurrence of anastomotic fistula after radical right hemicolectomy, and to further assess the predictive efficacy of related factors. Methods A total of 467 patients who und...
Feasibility and clinical value of deep learning reconstruction in accelerated MRI of shoulder
Objective To investigate the feasibility and clinical value of the deep learning reconstruction (DLR) algorithm in enhancing image quality and reducing scan time in shoulder MRI. Methods Fifty patients suspected of hav...