REPORTING AND MONITORING OF ADVERSE DRUG REACTIONS WITH CARDIAC DRUGS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 7
Abstract
Adverse drug reactions are a common medical problem, especially in patients who need multiple therapies. Patients with cardiovascular diseases are mostly on polypharmacy, so adverse effects of drug are quite common. The objective of the present study was to determine the severity and causality of adverse drug reactions in patients with cardiovascular drugs. This prospective and observational study enrolled patients who were on cardiac drugs and experienced adverse drug reaction. Naranjo ADR probability scale was used to establish the causality. A total of 231 ADRs were reported from 148 patients. Of these 148 patients, 39 patients were hospitalized primarily due to the development of ADRs, while 109 patients developed ADRs during hospital stay. Headache was the most frequent detected ADR (24.2%). The systems most commonly affected were the central nervous (33.3%) and gastrointestinal (16.5%). About 23.4% of the reactions were associated with calcium channel blockers followed by nitrates and ACE inhibitors. Assessing the severity and preventability of ADRs revealed that 1% of ADRs were detected as severe and 39% as preventable reactions. The main treatment of reaction was the withdrawal of the suspected drug(s). Occurrence of adverse drug reactions was common in Indian population and majority of them often were predictable and preventable. Monitoring ADRs in patients using cardiovascular drugs is a matter of importance since this class of medicines is usually used by elderly patients with critical conditions and underlying diseases.
Authors and Affiliations
Rohit Singhal , Khaleel Ahmed , Santani DD
Keywords
Related Articles
- EP ID EP150684
- DOI -
- Views 110
- Downloads 0
COMPARATIVE STUDY ON EFFECT OF SOLID DISPERSION TECHNIQUES FOR ENHANCEMENT OF DISSOLUTION RATE OF PIOGLITAZONE HCl
Pioglitazone hydrochloride is a novel antidiabetic drug in thiazolidinediones group and it improves insulin sensitivity in insulin resistant patients. One of the major problems with this drug is its low solubility in bio...
A NOVEL EXPLORING APPROACH OF CANCER CHEMOTHERAPY BY MULTIPLE EMULSION SYSTEM
Cancer is a disease characterized by uncontrolled multiplication and spread of abnormal forms of the body's own cells, leading cause of death worldwide, accounting for 7.6 million deaths (around 13% of all deaths) in 200...
PROTECTIVE ROLE OF ETHANOLIC EXTRACT OF HYBANTHUS ENNEASPERMUS ON MITOCHONDRIAL MEMBRANE Na+/K+ATPase, Ca2+ATPase AND Mg2+ATPase ACTIVITIES ON CARBON TETRACHLORIDE INDUCED OXIDATIVE STRESS IN RATS
In this present study, we evaluated the liver mitochondrial membrane ATPases activities on carbon tetrachloride induced oxidative stress in rats. Wistar strain male albino rats were divided into four groups. Group I ani...
SACCHARIFICATION BY FUNGI AND ETHANOL PRODUCTION BY BACTERIA USING LIGNOCELLULOSIC MATERIALS
Lignocellulosic material is one of the most abundant, renewable and inexpensive energy resources for bioethanol production. These materials are mainly composed of three groups of polymers namely cellulose, hemicellulose...
ASSOCIATION OF SERUM ALBUMIN CONCENTRATION AND PERIODONTITIS
Periodontal disease is a complex, multi-factorial, chronic inflammatory disease that involves degradation of periodontal structures, including alveolar bone. Many systemic diseases and disorders have been implicated as r...