Research progress of the molecular mechanism between vitamin D and type 2 diabetes mellitus in children and adolescents
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 7
Abstract
The incidence of type 2 diabetes mellitus (T2DM) is increasing globally. With the growing prevalence of obesity in childhood, the incidence of T2DM is also on the rise among children. Children with T2DM have worse persistent ability in glycemic control and are more prone to complications than adults. In recent years, some studies have found that vitamin D deficiency is closely related to T2DM in adult patients, and its relationship in children and adolescents has also been reported by more and more studies. In terms of mechanism, vitamin D posses the ability of improving insulin sensitivity and regulating insulin secretion, the former has a relationship with renin angiotensin aldosterone system(RAAS), peroxisome proliferator activated receptor(PPAR), oxidative stress system and other pathways, and later with protein kinase A (PKA), L-type voltage-dependent calcium channel (L-type VDCC), phospholipase C (PLC), ATP sensitive potassium channel（K<sub>ATP</sub>）and other signaling molecules. Thus, the review aims to explore the relationship between the deficiency of vitamin D and the incidence of T2DM in children and adolescents and its possible molecular mechanism, so as to provide a reference for the prevention and treatment of T2DM in children and adolescents.
Authors and Affiliations
ZHU Ting*, GU Wei, LIU Changwei
Keywords
Related Articles
- EP ID EP740720
- DOI 10.13429/j.cnki.cjcr.2024.07.006
- Views 48
- Downloads 1
Correlation between low density lipoprotein subtype and acute cerebral infarction in patients with type 2 diabetes mellitus
Objective To investigate the relationship between low density lipoprotein (LDL) subtypes and acute cerebral infarction (ACI) in type 2 diabetes mellitus (T2DM). Methods A retrospective analysis was conducted on 292 T2DM...
Fully automatic classification of lumbar disc degeneration based on deep learning
<b>Objective</b> To investigate the feasibility of a deep learning model for the fully automatic classification of disc degeneration based on lumbar structures on sagittal T2WI images. <b>Methods</b> The lumbar T2WI im...
Microsurgical treatment of severe aneurysmal subarachnoid hemorrhage: an analysis of 14 cases
"<b>Objective</b> To analyze the therapeutic effect of microsurgery on patients with severe aneurysmal subarachnoid hemorrhage (SaSAH). <b>Methods</b> A retrospective analysis was conducted on 14 SaSAH patients admit...
Diagnostic value of plasma chromogranin A levels for pheochromocytoma
"<b>Objective</b> To investigate the role of plasma chromogranin A (CgA) and free metanephrines (MNs) levels in the diagnosis of pheochromocytoma (PHEO). <b>Methods</b> The clinical data of 26 patients with PHEO (PHE...
Personalized anticoagulant therapy strategies for deep vein thrombosis
Deep vein thrombosis (DVT) is a common vascular condition that can lead to severe complications such as pulmonary embolism and chronic post-thrombotic syndrome. Anticoagulant therapy is the cornerstone of DVT management....