Research progress on the relationship between fibroblast growth factor and choroidal neovascularization
Journal Title: Eye Science (Yanke Xuebao) - Year 2020, Vol 35, Issue 2
Abstract
Choroidal neovascularization (CNV) can be found in ophthalmic diseases, such as age-related macular degeneration (AMD) and pathological myopia, which is an important cause of the development, deterioration and visual impairment of many fundus diseases. Many growth factors can promote the incidence and progression of CNV, including vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), transformation growth factor (TGF), insulin growth factor (IGF) and connective tissue growth factor (CTGF), etc. Among them, VEGF is the most important factor that promotes neovascularization. In recent years, anti-CNV measures, such as laser treatment and anti-VEGF drugs, have been adopted. However, anti-VEGF drugs yield drug resistance and certain adverse events. The pathogenesis of CNV has not been completely understood. FGF can exert both direct and indirect effects on fibroblasts and endothelial cells, and promote the CNV. FGF family-related factors may become new targets for CNV therapy, which may provide other options besides anti-VEGF therapy alone.
Authors and Affiliations
Lele LI, Manhui ZHU, Zhaoxian QIU, Aimin SANG
Keywords
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- EP ID EP763402
- DOI 10.3978/j.issn.1000-4432.2020.04.03
- Views 23
- Downloads 0
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