Research progress on the role and mechanism of melatonin in diabetic retinopathy
Journal Title: Eye Science (Yanke Xuebao) - Year 2020, Vol 35, Issue 3
Abstract
Diabetic retinopathy (DR) is a common microvascular complication caused by diabetes mellitus and a major cause of blindness in working-age population. Oxidative damage is an important mechanism leading to the occurrence of DR, and inflammation is also a critical factor involved in the development of DR. DR is characterized by autophagy damage. Melatonin (MT) is a molecule with highly potent anti-oxidative stress effect in vivo, and MT also exerts a strong inhibitory effect on inflammation, and suppresses the expression of various inflammatory factors. The eye is the key part of MT secretion besides pineal body and the eye tissue is the site where MT functions. MT has been proven to be a neuroprotective agent in experimental and clinical models of various eye diseases.
Authors and Affiliations
Jiayi GU, Manhui ZHU, Aimin SANG
Keywords
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- EP ID EP763417
- DOI 10.3978/j.issn.1000-4432.2020.06.01
- Views 16
- Downloads 0
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