Role of CRP, Micro- ESR and CPIS in Diagnosis of Ventilator Associated Pneumonia in Neonates at a Tertiary Care Hospital in Rajasthan.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 4
Abstract
Background: With increase in use of ventilator in NICU, Ventilator Associated Pneumonia has become a significant factor affecting the neonatal survival. Prevention with appropriate management of VAP requires early diagnosis. Methods: Hospital based observational study conducted on all children below 1 month of age kept on mechanical ventilation for at least 48 hrs & admitted in Intramural NICU (patient directly admitted in NICU) and Extramural NICU (patients referred from other hospital) . Results: Of 132 neonates who needed mechanical ventilation, 50(37.9%) developed VAP. Out of 50 cases who developed VAP, CRP was positive in 37 cases(52.1%) and 39 patients(81.2%) had CPIS >6. Sensitivity for CRP and CPIS was found to be 74% and 78% and specificity was 58.5% and 86.9% respectively while the positive predictive values were 52.1% and 81% and negative predictive values were 78.6% and 82% respectively. Significant risk factors associated with VAP were prematurity(OR=2.23), ventilation at early neonatal age(OR=2.5) and prolonged ventilation(OR=2.98). Conclusion: VAP contributes significantly to hospital acquired infection among neonates. Both CPIS and CRP were useful in screening the cases of VAP in neonates. When used in conjuction the tests were able to predict VAP even better.
Authors and Affiliations
G. S. Sengar
Keywords
Related Articles
- EP ID EP552716
- DOI -
- Views 128
- Downloads 0
Demographic and Clinicopathological Profile of Women with Ovarian Tumours at A Tertiary Care Centre.
Introduction: Ovarian tumours had a wide spectrum of clinical, morphological and histological pattern which affects their management. Ovarian tumour can occur at any age in a woman’s life and differ in type according to...
The Diagnostic Worth of Serum CA19-9 and CEA Levels in Anicteric Patients with Thick Walled Gallbladder
Introduction: Gallbladder carcinoma (GBC) is the most common malignancy of the biliary tract, accounting for 80–95% of biliary tract cancers.1 GBC affects over 140 000 patients worldwide and over100 000 die each year fro...
A case of prolonged restricted mouth opening-An approach to the diagnosis
Restriction of mouth opening can be due to a number of reasons; the connective tissue disorders are most rare of findings and are often ignored while marking differential diagnosis. Here we present an approach to diagnos...
Impact of Human Colostrum Associated Microbial Population on Neonatal Health
The first thick milk formed immediately after the delivery of newborns by memory glands of female mammals (including humans) is called colostrum. It is the basic primary requirement for the nourishment of newborns. It is...
Propofol and Thiopentone for total intravenous anaesthesia: A comparative study.
Background: To evaluate the safety and efficacy of propofol, to measure recovery times and to compare the return of psychomotor and cognitive function with thiopentone. Desigen of the study was a prospective randomized s...