SPECTRUM OF ADVERSE EFFECTS OF HAART THERAPY AMONG HIV INFECTED INDIVIDUALS- A PROSPECTIVE STUDY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 59
Abstract
BACKGROUND India is the world’s second largest country with HIV. The prevalence of HIV among Indian adults is 0.26%. In 2015, India had 2.1 million people living with HIV. HAART has reduced HIV mortality significantly. It is clear now that prolonged treatment that maintains suppression of plasma viraemia is unlikely to eradicate HIV. Therefore, therapy must be lifelong. Unfortunately, up to 25% of individuals discontinue HAART due to treatment failure, toxic effects or noncompliance. The aim of the study is to study prospectively various HAART drugs induced adverse reactions among HIV patients within 6 months of therapy. To evaluate the correlation between the adverse drug reactions with various demographic factors, clinical symptoms at the time of initiation of treatment, CD4 count at the baseline and various HAART regime. MATERIALS AND METHODS 200 HIV patients who fulfilled the NACO Guidelines for HAART therapy were started on treatment. All the investigations were done as per NACO Guidelines - Hb%, RBC indices, TC, DC, platelet count, peripheral smear morphology, blood sugar, lipid profile and CD4 count. Categorical measurements are presented in number (%). Chi-square test has been used to find out the significance of study parameters on categorical scale between 2 or more groups. RESULTS Out of 200 patients who were prospectively studied from January 2015 to October 2016, 60% had various adverse drug reactions. The M:F was 1.2:1 with a mean age of 37.2 ± 8.5 (23-66 yrs.), 32.1 ± 10.1 (16-70 yrs.), respectively. None of the demographic factors showed any relation with ADR. Gastrointestinal manifestations are most common ADR (40.8%) followed by fatigue (25.9%). Nevirapine base regime significantly associated with dermatological manifestations (p=0.008). Peripheral neuropathy correlated significantly with the stavudine usage (p=0.05). None of our patients were noncompliant with treatment. CONCLUSION Adverse drug reactions are common during early part of HAART. Gastrointestinal manifestations are most common during this period. Most of the adverse drug reactions can easily recognised and early treatment will not affect the adherence pattern with HAART
Authors and Affiliations
Venkateswara Rao K. S. S, Sreenivasulu V
Keywords
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- EP ID EP226345
- DOI 10.14260/Jemds/2017/947
- Views 127
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