STUDY OF CHEMICAL COMPOSITION OF GARLIC OIL AND COMPARATIVE ANALYSIS OF CO-TRIMOXAZOLE IN RESPONSE TO IN VITRO ANTIBACTERIAL ACTIVITY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2014, Vol 5, Issue 2
Abstract
During the last 20 years, traditional system of medicine has become a topic of global importance. Allium sativum also known as garlic, belong to the Genus Allium is one of the representatives of this system of medicine. In this study, the garlic oil was extracted by solvent extraction using n-hexane as solvent. The reported percentage yield of oil was 1.1 %, and the specific gravity was 0.90 g/ml. Gas Chromatography-Mass Spectrometry analysis of oil showed the presence of four compounds Diallylmonosulfide, Trisulfide methyl 2 propenyl, Diallyl trisulfide, Dimethyl tetrasulfide and their GC retention times were 6.2 minutes, 9.0 minutes, 5.9 minutes and 8.1 minutes respectively. The chemical equivalence of drugs plays an important role in their quality assurance. Five different brands of co-trimoxazole were studied for qualitative and quantitative analysis. The result of study showed that samples A-E had 101.29 %, 100.38 %, 99.35 %, 98.65 % and 97.31 % of sulfamethoxazole and 99.40 %, 98.69 %, 96.46 %, 89.25 % and 88.67 % of trimethoprim content. Only three brands A-C confirmed to official monograph for trimethoprim but two samples D and E showed lower values than standard values. This brings the need for drug agencies to monitor the quality of the drugs to check adulteration. The comparison of antibacterial activity of garlic extract and the drug was carried out in-vitro against E-coli, and the result of the study showed that garlic has good anti-bacterial activity with respect to co-trimoxazole.
Authors and Affiliations
Rainy Gupta , Amita Sharma , Preeti Maina , R. N. Shukla
Keywords
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- EP ID EP162433
- DOI 10.7897/2230-8407.050220
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