STUDY ON METABONOMICS MECHANISM OF COMPATIBILITY OF GINSENOSIDES AND TENUIGENINS ON ALZHEIMER’S DISEASE RATS BASED ON UPLC-MS
Journal Title: Topics in Chemical & Material Engineering (TCME) - Year 2018, Vol 1, Issue 1
Abstract
Ginseng and polygala tenuifolia are traditional Chinese medcine for the treatment of Alzheimer’s disease (AD). Ginsenoside and tenuigenin are the major effective compounds found in ginseng and polygala tenuifolia, respectively. In this study, a urinary metabonomics method based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight high definition mass spectrometry was performed to assess the holistic mechanism of the compatibility of ginsenosides and tenuigenins for treating AD in rats. 30 male rats were randomly divided into 3 groups, named as the normal group (NG), the model group (MG), the treatment group (TG). The MG and TG were induced for modeling AD by using D-galactose combined with aluminum trichloride. Multivariate statistical approaches, such as principal component analysis (PCA) and orthogonal projection to latent structures squares-discriminant analysis (OPLS-DA) were used to distinguish 3 groups and find potential biomarkers. As results shown, there was a clear separation between the 3 groups in the PCA. Ten potential biomarkers had been identified using OPLS-DA and S-plot, which belonged to tryptophan metabolism, taurine and hypotaurine metabolism and inositol phosphate metabolism. This study shows that metabonomics is a powerful methodology, which could further explore the mechanism of compatibility of ginsenosides and tenuigenins in the treatment of AD.
Authors and Affiliations
Yan Zhang, Hui Li, Guan Wang, Ben Liu, Fan Zhang, Hongqi Wang, Wunjing You, Cong Ni, Wenhao Ma
Keywords
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- EP ID EP414790
- DOI 10.26480/icnmim.01.2018.280.283
- Views 59
- Downloads 0
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