Study on the synergistic antioxidant effect of resveratrol and vitamin E
Journal Title: Journal of Henan Agricultural University - Year 2022, Vol 56, Issue 6
Abstract
[Objective] This study was designed to study the antioxidative interaction of resveratrol and vitamin E and to explore the synergistic effect of active ingredients under the combined action of anti-oxidation effect. [Methods] Using TBHQ as positive control group, and DPPH, ABTS, and FRAP as detection indexes, and the antioxidant effects of RES and vitamin E were evaluated in RES group, VE group, DARV group and ARV group (half dose of DARV group). [Results] The dosages of RES, VE, DARV and ARV were significantly correlated with the antioxidant activity and showed some positive synergistic effect(P<0.05). The IC50 value of DARV group decreased significantly after RES and VE were combined, which was smaller than that of single component RES group and VE group (P<0.05), indicating that the combination of RES and vitamin E showed synergistic antioxidant effect, which had better antioxidant effect than the single use of each component. RES was the primary agent and VE was the secondary agent in the combined action. Using DPPH·as the detection index, RES∶VE showed additive effect at 1∶2-1∶3 (0.95<CI<1.05), which had good synergistic effect at 1∶1-7∶1 (CI<0.95). And the IC50 was 0.011 g·L-1 (CI<0.95) at 3∶1 for RES∶VE, when the antioxidant had the strongest positive synergistic effect. [Conclusion] Resveratrol and vitam in E have a good antioxidant synergistic effect under a certain proportion of use, which provides a theoretical basis for the future research and development of active ingredients combined in health food or auxiliary drugs.
Authors and Affiliations
Na WANG, Enguang GAO, Na LI, Qingqing LIU, Fan WANG, Hongtao REN, Zhengbang LI, Qiuying YU
Keywords
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- EP ID EP769145
- DOI 10.16445/j.cnki.1000-2340.20221107.002
- Views 4
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