Susceptibility Patterns of Vulvovaginal Candida isolates against Antifungal Drugs in a Tertiary Care Teaching Hospital, West Bengal, India
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 11
Abstract
Vulvovaginal candidiasis (VVC) is a common fungal infection among adult women during reproductive ages. This study was carried out to isolate Candida and to determine the species prevalence and the antifungal susceptibility of Candida species isolated from patients with VVC. A total of 239 women of reproductive age group (18-50years) with complaints of vaginal discharge and clinically diagnosed as vulvovaginal candidiasis were included in the study group. The study was conducted at Obstetrics and Gynaecology OPD (out patients department) of Malda Medical College, Malda and in the department of Microbiology of Malda Medical College, Malda. Two high vaginal swabs were collected from each patient, one for direct microscopy, another for culture on Sabouraud dextrose agar (SDA) with chloramphenicol. Isolates on SDA were identified and speciated using standard mycological tests – microscopic examination of Gram stained smear, germ tube test, sugar assimilation test and morphology on corn meal agar. Antifungal susceptibility testing was performed by modified Kirby-Bauer disc diffusion method. A total of 91grew Candida isolates giving a prevalence of 38.08% and highest numbers of isolates (53, 58.24%) were C. albicans followed by C. glabrata (17, 18.68%). Antifungal susceptibility testing showed that Candida isolates were more sensitive to Voriconazole, Itraconazole and Ketoconazole, compared to that of Fluconazole, Clotrimazole, Miconazole and Nystatin. Although Fluconazole still appeared to be active against C. albicans, high resistance rate of Nonalbicans Candida (NAC) spp. against the drug may support a search for alternative antifungal drugs when treating VVC caused by NAC spp.
Authors and Affiliations
Tapati Mondal, Arnab Kumar Mandal, Pratip Kumar Kundu
Keywords
Related Articles
- EP ID EP582679
- DOI 10.9790/0853-1711105863
- Views 66
- Downloads 0
“Clinical Study on Platelet Rich Plasma in Wound Healing”
Introduction: wound management is a challenging task to the surgeon and a debilitating issue to the patients. The general treatment including the expert care in dressings, meticulous use of antibiotics, Negative pressure...
Diagnosis of peripheral artery disease in Saudi Population - CTA and MRA Based Study
The current study highlight the main findings in lower limb arteries diagnosed by Computerized Tomography Angiography(CTA) and Magnetic Resonance Angiography (MRA) done for Saudi Arabia population whom were smokers, hype...
Bisap:A New Method For Assessing Severity And Mortality Of Acute Pancreatitis
OBJECTIVES: This study was conducted with aim of to determine the ability of BISAP (Bedside index for severity in acute pancreatitis score) score to predict mortality and severity in acute pancreatitis. MATERIAL AND METH...
Watch out- severe hyperthermia with misoprostol!
Misoprostol, used for the prevention and management of post partum haemorrhage, can have adverse effects and should be monitored carefully. We discuss a 30 year old primigravida who received misoprostol for post partum h...
Hepatitis B Vaccination in Chronic Kidney Disease:- Experience in A Tertiary Care Centre
Background: The study was conducted to examine the seroconversion rate for hepatitis B vaccination in Chronic Kidney Disease (CKD) patients and the factors which influence the sero conversion rate . Methodology: This is...