SYNTHESIS, DOCKING AND BIOLOGICAL STUDIES OF THE LINEAR TETRAPEPTIDE PWPV
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6
Abstract
Linear Tetrapeptides L-PWPV (Pro-Trp-Pro-Val) was designed and synthesized by solution phase peptide synthesis based on dock score. The molecular docking studies of the designed tetrapeptide L-PWPV was carried out using Molegro Virtual Docker software for tumor cancer protein(1OLG). The linear tetrapeptide was synthesized by coupling protected amino acids (dipeptides) using EDC (ethyl-3-(N,N-dimethylamino)propyl carbodiimide) as coupling reagent. The compounds were analyzed by FTIR, 1H NMR and MASS data and subjected to antioxidant activity using 1,1-dipheny-2-picryl-hydrazil (DPPH) method and insecticidal activity using Morita et al method.
Authors and Affiliations
M. Himaja , Sanjay S , Poppy Das, Munirajasekhar D, A. A Karigar
Keywords
Related Articles
- EP ID EP156070
- DOI -
- Views 113
- Downloads 0
QSAR MODELING OF GELATINASE INHIBITORS: MLR APPROACH
Matrix metalloproteinases are regulated by growth factors, hormones, cytokines etc. and endogenous inhibitors control them. Over expression of matrix metalloproteinases can lead to a variety of pathological disorders whi...
FAST DISSOLVING TABLETS: AN UPDATE
Fast dissolving tablets are dissolving rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. Other...
ISOLATION OF Α-GLUCOSIDASE INHIBITORY ACTIVE COMPOUNDS FROM ETHANOL EXTRACT OF KAYU TUAH (ANTIDESMA CELEBICUM MIQ.) LEAVES
Antidesma celebicum Miq. belongs to Euphorbiaceae family has been used as antidiabetic traditional medicine. The aim of the research was to isolate the α-Glucosidase inhibitory compound from ethanol extract of Antidesma...
EFFECT OF AQUEOUS EXTRACT OF PUNICA GRANATUM FLOWER ON BIOMARKERS AND ECG CHANGES IN ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN RATS
The present study was designed to investigate the effect of aqueous extract of Punica granatum flower (PG) against isoproterenol (ISO) induced myocardial infarction (MI) in rats by studying cardiac markers and electrocar...
THERAPEUTIC SIGNIFICANCE OF QUINOLINE DERIVATIVES AS ANTIMICROBIAL AGENTS
Microbial infections are one of the leading diseases which are responsible for millions of deaths every year because of lack of effective antimicrobial therapy and this situation becomes more complicated because of micro...