SYNTHESIS OF SOME NOVEL PERYLENE DI IMIDES AND EVALUATION OF THEIR ANTI CANCER ACTIVITY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 8
Abstract
Objective: The main objective of the study is to synthesis some novel perylene di imides and to evaluate for anti oxidant activity and anticancer activity.Methods: Antioxidant assay was carried on to study the reducing activity of the compounds. The cytotoxicity assay was studied to find the best potent compound among the synthesized compound by using the HCT-116, a colon cancer cell line. Synthesized substituted amine derivatives of perylene di imides. From the evaluation study Compound, A shows potent activity when compared with the standard drug 5-Fluorouracil.Results: The results of the total antioxidant capacity assay of perylene compounds are evaluated by the 1,1-diphenyl-2-picryl hydrazyl (DPPH) method and nitric oxide scavenging method. All the synthesized compounds are evaluated for their antioxidant power. From the results of DPPH and nitric oxide scavenging assay, Compound A, B, C and D showed potent activity when compared with the standard. For further evaluation of cell line studies, based upon the IC50 values, Compound A, B and C were taken for study. The molecular modeling data’s are exactly correlated with the in vitro studies. We have used 5-Fluorouracil and PIPER as a standard for in vitro study and molecular modeling study respectively.Conclusions: From the results, Compound A will be efficient to inhibit telomerase enzyme and the Compound A will be effective for anti-cancer therapy.
Authors and Affiliations
Hemalatha C N, Vijey Aanandhi M
Keywords
Related Articles
- EP ID EP567378
- DOI 10.22159/ajpcr.2018.v11i8.26539
- Views 130
- Downloads 0
MONITORING AND ANALYSIS OF ADVERSE DRUG REACTIONS IN A PRIVATE TERTIARY CARE TEACHING HOSPITAL
 Objectives: To monitor and analyse the suspected adverse drug reactions (ADRs) reported at Vydehi Hospital, Bengaluru.Methods: A prospective observational study was conducted between July 2011 and August 2012. Suspecte...
CLEANING VALIDATION OF A SIMPLE AND RAPID REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR THE SIMULTANEOUS ESTIMATION OF ASPIRIN AND ROSUVASTATIN
Objective: This study describes a new, simple, precise, accurate, and reproducible reversed-phase high-performance liquid chromatography (RP-HPLC) cleaning validation method for simultaneous estimation of rosuvastatin an...
EVALUTION OF IN VITRO ANTI-ANGIOGENESIS ACTIVITY ON METHANOLIC EXTRACT OF Clematis buchaniana PLANT
Objective: Angiogenesis plays an important role in embryonic development and various physiological processes. However, excessive angiogenesis is associated with several pathological conditions including cancer. Clematis...
DETERMINATION OF BIOLOGICAL ACTIVITIES OF THREE MARINE ALGAE COLLECTED FROM VISAKHAPATNAM COAST
  Objective: Determination of biological activities of marine algae collected from the Visakhapatnam coastal region.Methods: Antibacterial activity of algal extracts determined by the well diffusion method, antioxidant...
ANTICANCER ACTIVITY OF ZINC OXIDE AND ZINC OXIDE/CADMIUM SULFIDE NANOCOMPOSITES
Objective: The objective of this study is to investigate the anticancer activity of zinc oxide (ZnO) and ZnO/cadmium sulfide (CdS) nanoparticles (NPs). These NPs were active index against five human tumor cell lines, nam...