THE ASSOCIATION OF ki67 PROLIFERATION MARKER WITH ESTROGEN, PROGESTERONE AND HER2 MARKERS AMONG SUDANESE FEMALES WITH BREAST CANCER
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2014, Vol 3, Issue 6
Abstract
Background: Breast cancer aggressiveness can be correlated with proliferation status of tumor cells, which can be ascertained with tumor grade and Ki67 indexing. We therefore aimed to determine associations of the Ki67 index with other prognostic markers like tumor size, grade, ER, PR and HER2 status.This study aimed to determine the association of ki67 tumor marker with ER, PR, and HER2 markers among Sudanese females with breast cancers during January to august 2012. Methods: This is a descriptive retrospective study, aimed to detection the association of ki67 tumor marker with PR, ER, HER2 as well as clinicopathological data of breast cancer among Sudanese female attending Radiation and isotope center-Khartoum. 50 Paraffin blocks that were previously diagnosed as breast carcinoma were randomly selected and each paraffin block two sections of 3μm thick one for H&E stain and anther to immunohistochemicaln stain was performed by the DAKO envision method.
Authors and Affiliations
Reem Mohammed Fadl Elmoula| M.s.c Department of Histopathology and Cytology Sudan University of Science and Technology, Sudan., and Hassan Elsiddig Hassan Farag Alla| Assistant Professor of Histopathology and Cytology (SUST).
Keywords
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