THE EFFECT OF INDONESIAN VELVET BEAN EXTRACT ON THE FERTILITY OF ALBINO MALE MICE
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 2
Abstract
Objective: This research aims to determine the dose of Indonesian velvet bean (Mucuna pruriens) extract which has significant effect on the ferlitity mice (concentration, motility and morphology of mice sperm). The extract is expected to become an alternative infertility herbal medicine relatively more secure and affordable replacing synthetic hormonal drugs which tend to have negative effects.Methods: The seed was taken from Yogyakarta Indonesia. Fertility test was done to fertile adult male albino mice 12 w old, weighing 25-35 grams. Fertility tests performed on seven groups of mice; i.e. negative control, positive control and treatment groups (five dose levels at 50, 100, 150, 200 and 250 mg/kg body weight). Subsequent fertility test results were statistically tested, including tests of normality (Kolmogorov-Sminov) followed by T test (Independent-Samples T Test).Results: The sperm concentration and motility increased as an increased dose of seed extract was applied, as well as decreased abnormal morphology. The highest change in the quality and quantity of sperm occurred at the dose of 250 mg/kg body weight with increased sperm concentration of about 22 million, sperm motility increased by 18% and decreased abnormal sperm morphology by 12%. Statistical analysis showed a significant increase in sperm concentration and motility at doses of 100, 150, 200 and 250 mg/kg body weight, whereas a significant decrease of abnormal sperm morphology was found at doses of 150, 200 and 250 mg/kg body weight.Conclusion: Based on this study it is concluded that Indonesian velvet beans seed extract can increased the fertility of albino male mice significantly at dose level 250 mg/kg body weight.
Authors and Affiliations
Ratnaningsih Eko Sardjono, Viensa Pradipta, Iqbal Musthapa
Keywords
Related Articles
- EP ID EP575985
- DOI 10.22159/ijpps.2016v8s2.15223
- Views 92
- Downloads 0
PROCESS AND PARAMETERS AFFECTING DRUG RELEASE PERFORMANCE OF PREPARED CROSS-LINKED ALGINATE HYDROGEL BEADS FOR EZETIMIBE
Objective: The objective of this study was to formulate an oral sustained release delivery system of ezetimibe mucoadhesive beads by ionic gelation technique based on sodium alginate used as a hydrophilic carrier in comb...
ANTI-OBESITY EFFECT OF RESVERATROL IN RATS ON HIGH FAT DIET THROUGH REGULATION OF GENE EXPRESSION OF VISCERAL WHITE ADIPOSE TISSUE
Objective: Obesity is a chronic disease associated with serious health complications including inflammation, insulin resistance, metabolic syndrome, cardiovascular complications and several types of cancers. So this stud...
GANGRENE PRECIPITATED BY CISPLATIN BASED CONCURRENT CHEMORADIATION IN CANCER CERVIX
Gangrene of hand leading to its amputation may be the worst after-effects of cisplatin. Here we report the case of cisplatin-induced gangrene in a patient of the cancer cervix who was treated with concurrent chemo radiat...
A STUDY TO PREDICT ANTI-INFLAMMATORY ACTIVITY OF EUGENOL, MYRISTICIN, AND LIMONENE OF CINNAMOMUM SINTOC
Objective: In this work we predicted anti-inflammatory activity of volatile oil of C. sintoc L.Methods: Molecular docking was performed to predict the binding modes of eugenol, myristicin, and limonene chemical constitue...
HEALING POTENCY OF HAEMATOCOCCUS PLUVIALIS EXTRACT FOR TREATING TYPE 2 DIABETES IN RATS
Objective: The present study aims to evaluate the antidiabetic effect of ethanolic extract of Haematococcus pluvialis (H. pluvialis) in streptozotocin (STZ)-induced diabetic rats.Methods: The antidiabetic activity of H....