The Renal Toxicity of Welding Fumes in Heavy Equipment Manufacturer Workers
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2015, Vol 4, Issue 3
Abstract
Exposure to welding fumes in the workplace has been associated with decreasing renal function. We studied renal function parameters in men workers from heavy equipment manufacturer exposed to welding fumes. This study aimed to evaluate renal function status among worker exposed to welding fumes. A case-control design, random study, was conducted among welder (35 subjects) and nonwelder (35 subjects) with more than 1 years experience in the same job task in a heavy equipment manufacturer. All subjects were completed physical examination, informed consent, questionnaire and laboratory tests. Renal function was measured as creatinine serum using enzimatic method. Urinary heavy metals level was analyzed using inductively coupled plasma mass spectrometry. Comparisson analysis between group was performed to determined median level for each variable. Linear regression model was developed to predict renal function function parameter status urinary heavy metals level as variable. This study showed there were higher creatinine serum, chromium, iron, manganese and nickel in welder than non welder(p<0.05). After multivariate analysis, urinary nickel is a predictor for renal function status among welder. Exposure to welding fumes was significantly correlated with renal function status in welder. Nickel is the predictive variable for renal function. Although statistically significant but in clinical field needs carefully interpreting data.
Authors and Affiliations
Mulyana Mulyana, Nuri P. Adi, Meily Kurniawidjaja, Vani N. Pratami, Andi Wijaya, Irawan Yusuf
Keywords
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- EP ID EP357397
- DOI 10.15416/ijcp.2015.4.3.199
- Views 100
- Downloads 0
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