THE ROLE OF CSF PCR IN EARLY DIAGNOSIS OF TUBERCULAR MENINGITIS: A STUDY FROM BIDAR DISTRICT
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2014, Vol 1, Issue 6
Abstract
The objective of this study was a study the clinical features and laboratory profile including acid fast bacillus microscopy, cerebrospinal fluid (CSF) culture and M tuberculosis polymerase chain reaction (PCR) for an early diagnosis of tuberculous meningitis. METHODOLOGY: 40 consecutive patients, fulfilling the clinical criteria of tuberculosis meningitis, were included in the study. All patients were subjected to detailed clinical and laboratory evaluation and radiological tests. CSF acid fast bacillus microscopy culture and PCR were carried out in all and results were analyzed. RESULTS: Majority of the patients presented with fever headache, vomiting and signs of meningeal irritation. Ziehl –Neelsen staining for acid fast bacillus was positive in 4% cases, culture in 18% cases and CSF PCR for mycobacterium tuberculosis was positive in 68%. Milliary pattern on chest x-ray was seen in 16% and CNS tuberculomas were seen in 14% cases. CONCLUSION: The CSF PCR estimation in clinically suspected cases of tuberculous meningitis may be an extremely valuable test for early diagnosis and institution of specific therapy.
Authors and Affiliations
Vijay Kumar B. A, Shashank Kulkarni, Yogesh Kamshetty, Shivalingappa Patil, Deepa V. A. , Thirumala Uppar
Keywords
Related Articles
- EP ID EP221396
- DOI 10.18410/jebmh/2014/58
- Views 117
- Downloads 0
LIMB LENGTH DISCREPANCY FOLLOWING CONSERVATIVE MANAGEMENT OF FEMORAL SHAFT FRACTURES IN CHILDREN, CLINICAL REVIEW AND RECOMMENDATIONS
BACKGROUND Shaft of femur is third most common location of fractures among children. In children there is strong potential for early union and remodeling even with conservative treatment. Conservative treatment is an acc...
STUDY OF ASSOCIATION OF PULMONARY TUBERCULOSIS AND DIABETES MELLITUS IN A TERTIARY CARE CENTRE
BACKGROUND Tuberculosis continues to be one of the most prevalent infection in the world despite all efforts to eliminate it. Patients with diabetes are more susceptible to infections as hyperglycaemia decreases the abil...
MANAGEMENT OF A PATIENT WITH ARDS: A CASE REPORT
Acute Respiratory Distress Syndrome (ARDS) is a permeability pulmonary edema characterized by increased permeability of pulmonary capillary endothelial cells and alveolar epithelial cells, leading to hypoxemia that is re...
AN ASSESSMENT OF CAUSE OF VISUAL IMPAIRMENT AMONG STUDENTS OF BLIND SCHOOL IN BASTAR DISTRICT, CHHATTISGARH
BACKGROUND About 1.4 million children in the world are either visually impaired or blind causing hindrance to lead a normal lifestyle. Among various reasons for childhood blindness, the most common preventable cause of b...
CARDIAC MYXOMA- A STUDY OF 10 CASES
BACKGROUND Myxoma is the most common primary tumour of the heart in adults with age range of 30 to 60 years. About 90% of them are situated in left atrium. Here we present a study of 10 cases of cardiac myxomas. MATERIAL...