The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease
Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 3
Abstract
Alzheimer’s disease (AD), a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofbrillary tangles and neuro-inflammation. Inflammation of the brain is a key pathological hallmark of AD. Tus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators. In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain. Tis review provides an overview of the functions and activities of inflammatory mediators in AD. An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the feld of AD and similar diseases.
Authors and Affiliations
Gholamreza Azizi| Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran, Research Center for Immunodefciencies, Children’s Medical Center, Shadi S. Navabi| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Ahmed Al-Shukaili| Health & Social Services Sector, Te Research Council Oman, Muscat, Oman, Mir H. Seyedzadeh| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Reza Yazdani| Research Center for Immunodefciencies, Children’s Medical Center, Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, Abbas Mirshafey| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Keywords
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