Thyroid-Induced Toxicity of Check-Point Inhibitors Immunotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer
Journal Title: Journal of Endocrinology and Diabetes - Year 2016, Vol 3, Issue 1
Abstract
Immunotherapy represents a new strategy in the fight against cancer diseases based on the key role that immune system plays to identify and destroy foreign or abnormal cells in the body, including tumor cells. Nowadays, two immune-checkpoint inhibitors with antitumor activity have been approved for treatment of advanced nonsmall cell lung cancer (NSCLC): Nivolumab and Pembrolizumab (antiprogrammed death 1, anti-PD-1). However, these inhibitors are related to a unique class of mechanism-based toxicities, termed immunerelated Adverse Events (irAEs) that have an autoimmune etiology. Among endocrinopathies due to immuno-checkpoint antibodies, the thyreopathies are frequently reported, probably because antithyroid autoimmunity represents the most common autoimmune disease in humans. The spectrum of thyreopathies reported in NSCLC patients during therapy with immune-checkpoint inhibitors includes: thyroiditis, primary and secondary hypothyroidism and hyperthyroidism. In view of the ongoing increased employment of these drugs in the treatment of NSCLC, irAEs, described in selected patients in clinical trials, will began more frequent and with different clinical impact in routine practice. This manuscript focuses particularly on thyroid disorders induced by immunotherapies employed in NSCLC, in order to suggest the strategies for identify, diagnose and treat them without affecting patient outcomes.
Authors and Affiliations
Cesare Gridelli, Emanuela Rossi, Assunta Sgambato, Giovanni De Chiara, Fortunato Ciardiello
Keywords
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- EP ID EP333392
- DOI 10.15226/2374-6890/3/1/00143
- Views 146
- Downloads 0
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