To evaluate the effect of pyridostigmine on blood glucose levels in euglycemic albino rats through OGTT
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2017, Vol 4, Issue 4
Abstract
Introduction: The effect of Pyridostigmine on blood glucose levels in euglycemic albino rats through OGTT. Methods: Twelve Swiss albino rats weighing around 150-200gmsof either sex were randomly selected from the central animal facility, and divided into two groups. The control group received distilled water (25ml/kg body wt.), test group received Pyridostigmine (3.6mg/kg/day) for 5 days. All the drugs were given per orally. On the fifth day, following overnight fasting, 1 hour after drug administration OGTT was performed, by administering oral glucose in dose of 0.6gm/kg body weight. The capillary blood glucose level of both the groups were measured at 0, 60 and 150 minutes, by rat tail snipping method using (ACCUCHEK) glucometer. Results: The Capillary Blood Glucose levels of Pyridostigmine group was less when compared to control group at all-time intervals and was statistically significant when compared to control at all the time intervals. Conclusion: Pyridostigmine showed the hypoglycemic activity when given for 5 days orally in euglycemic albino rats through OGTT.
Authors and Affiliations
Siddamma Amoghimath, Suresha R N, Shruthi S L
Keywords
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- DOI 10.18231/2393-9087.2017.0043
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