Topical clonazepam in the treatment of burning mouth syndrome (BMS) – preliminary report.
Journal Title: Journal of Stomatology (Czasopismo Stomatologiczne) - Year 2012, Vol 65, Issue 2
Abstract
Introduction. Burning mouth syndrome is a chronic oral pain condition without any signs of mucosal pathology, described most often as burning of the tongue. The drugs used in the therapy of BMS belong to different pharmacological groups: antidepressants, antiepileptic drugs, analgesics and mucosal protectors. Topical clonazepam showed the best efficacy in treatment of BMS. Aim of the study. To evaluate the efficacy of the topical use of clonazepam in the group of 30 patients with BMS. Material and methods. 30 patients with BMS underwent an anamnesis, a physical examination and psychological test: State-Trait Anxiety Inventory (STAI). All the patients were instructed to suck a 1 mg clonazepam tablet 3 times a day and then to spit out. The intensity of burning was assessed on the VAS scale: at baseline and after 3, 6 and 12 weeks of treatment. The patients were asked about the side effects of the drug. Results. 20 patients completed the whole 3-month treatment. Very effective treatment was observed in 13 patients (in 5 cases it was total remission), partially effective treatment was observed in 4 cases and treatment failure in 3 patients. The side effects were reported by 13 patients. Among the group examined by psychologist (30 subjects), 56.5% had high scores in trait anxiety, 30% had high degree of state anxiety. Conclusion. Topical clonazepam alleviates oral burning in most cases. It is essential to perform subsequent studies on larger groups of patients with the use of placebo. Psychological factors such as anxiety and stress can be the cause of burning mouth syndrome.
Authors and Affiliations
Magdalena Mendak-Ziółko, Małgorzata Radwan-Oczko
Keywords
Related Articles
- EP ID EP57608
- DOI -
- Views 99
- Downloads 0
Stefan Włoch (1926-2012) distinguished professor and a trusted friend
In our life, also when we are adults, there is a need for point of reference, a role model we search for – not always being aware of this fact – among people with more experience in private and professional life. In this...
Scottish Dental Clinical Effectiveness Programme Prevention and Management of Dental Caries in Children. Dental Clinical Guidance. PART II Defining Needs and Developing a Personal Care Plan. Managing Pain (if present). Caries Prevention.
The information gathered from the assessment of the child will enable a diagnosis to be formulated. From this, the needs to be addressed and the proposed interventions to manage them can be listed and prioritised into a...
Oral health condition in a 6.5-year-old girl with Prader-Willie syndrome – case report
Introduction: The Prader-Willi syndrome is associated with an abnormality occurring within chromosome pairs (15q11-13). During the neonatal period, PWS children are characterized by genital hypoplasia and muscle hypotens...
Blood flowinmandibularvessels–itsevaluationandprognosticimplications including Doppler techniques – review of literature
Introduction: Alveolar bone atrophy, mainly in the mandible, is a common clinical problem in patients undergoing prosthetic treatment.Aim of the study: To analyze hypotheses concerning alveolar atrophy pathogenesis on th...
Rozwój zęba w świetle badań pacjentów pozostających w remisji choroby nowotworowej*
Wprowadzenie. Mechanizmy rozwojowe, które odpowiadają za ostateczny kształt i wielkość zęba, wciąż nie są dostatecznie poznane. Znajomość dokładnego czasu zastosowania leczenia przeciwnowotworowego w konfrontacji z powst...