Ultrasound morphology of the thyroid gland among pregnant women in the moderate iodine deficient region of Lubumbashi, DR Congo
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Background: Iodine deficiency occurs in varying degrees worldwide. When it occurs during pregnancy, it leads to morphological and functional changes in the maternal thyroid gland with fatal consequences on the pregnancy’s way out. The aim was to evaluate morphological condition of the thyroid gland and to compare this to thyroid stimulating hormone (TSH) levels as well as to urinary iodine levels among pregnant women in Lubumbashi Method:a cross-sectional study among 225 pregnant women from three areas: Lubumbashi University Clinic (urban zone), Bongonga Health Center (semi-urban zone) and KatubaHospital (urban-rural zone) between March 2009 and February 2012. Thyroid ultrasounds were performed using 7.5 MHz probe frequency. TSH, T4L and T3L was performed by enzyme immunoassay using ETI Diasorin equipment. Urinary iodine was measured after oxidation by ammonium persulfate. In order to analyze the data, the software Epi-InfoTM Version 3.3.2 was used. Results:12% of pregnant women had thyroid abnormality. Pregnant women with a subclinical goiter or a nodule were on average older than those which no morphological abnormalities (p=0.01) and the family history of goiter was more frequent among them (p=0.01). Women with subclinical goiter had a lower median urinary iodine concentration. Among the 28 women with subclinical hypothyroidism, only 4 (14%) showed morphological abnormalities on the ultrasound. Conclusion: morphological and functional thyroid changes are relatively frequent among pregnant women in Lubumbashi. Given the impact of these disorders on pregnancy and the fetus, quality control on commercialized salt in these areas must be strengthened and Thyroid function monitored.
Authors and Affiliations
TwiteKabange Eugène, Laurence Habimana, Pierre Bernard, BienvenueIlunga Banza, Etienne Kasongo Mpoyo, Damien Gruson, Philippe Donnen, NyemboMukena Christophe, KalengaMuenzeKayamba Prosper, Annie Robert
Keywords
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- EP ID EP377354
- DOI 10.9790/0853-1707070410.
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