Uremic Toxin and Endothelium
Journal Title: Journal of Analytical Bio-Science - Year 2012, Vol 35, Issue 3
Abstract
Recent studies have verified the positive correlation between chronic kidney disease (CKD) and cardiovascular disease (CVD), which is called cardio-renal syndrome. CKD patients display an impaired endothelium-dependent vasodilatation, which is one of the initial steps in the development of CVD. However little is known about the mechanisms involved. In a patient with CKD, circulating uremic toxins are elevated are well-known to cause ''uremia''. Recently, these uremic toxins are reported to augment the production of inflammatory cytokines as well as reactive oxygen species in vasculartures, which in turn impair endothelial function. Those toxins, therefore, must become recognized as cardiovascular toxins. Here, we review the pathophysiological role of uremic toxins in cardio-renal syndrome
Authors and Affiliations
Junko Tatebe, Toshisuke Morita
Keywords
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