[u][/u]Biological activity and stability in vitro of polyphenolic extracts as potential dietary supplements
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Introduction: In times of worsening civilization diseases the interest in natural healing substances is on the increase. To reduce unwanted side effects of many synthetic drugs, it is reasonable to introduce to the daily diet foods rich in natural compounds of plant origin that are beneficial for health. The purpose of the study was to determine the biological activity and stability of selected ethanol extracts of the fruit of chokeberry, blackcurrant, hawthorn, rosehip, quince and Japanese quince as potential nutraceuticals.Materials and methods: Antioxidant activity of the extracts was determined in relation to model phospholipid membranes (IC50 PC). Antiradical activity was determined in a test with the DPPH• radical (IC50 DPPH). Also the inhibition of enzymatic (1-LOX) oxidation of linoleic acid was determined at the beginning of the period of storage of the extracts at room temperature and after 12 months. Results: After 12 months of storage the highest antioxidant stability was shown by blackcurrant extract (1.5% increase in IC50 PC), the highest antiradical stability by quince extract (1.0% reduction in IC50 DPPH), and the highest stability of 1-LOX enzyme inhibition by chokeberry extract (6.3% reduction in inhibition at a concentration of 8 μg∙ml-1). Japanese quince extract showed the strongest regenerating properties with respect to oxidized phospholipid membranes and the highest ability to eliminate the free radical DPPH•. Conclusion: It can be concluded that the ethanol extracts of the fruits (in particular blackcurrant, chokeberry and Japanese quince) are a potential source of dietary supplements of expected effectiveness in preventive treatment.
Authors and Affiliations
Paulina Strugała, Janina Gabrielska
Keywords
Related Articles
- EP ID EP67462
- DOI -
- Views 147
- Downloads 0
Deep vein thrombosis of the lower limbs in intravenous drug users
Addiction to intravenously administered drugs has been a serious epidemiological problem for years. Among the related health complications, deep vein thrombosis (DVT) is one of the most important. This paper provides an...
Zastosowanie wirusa pęcherzykowatego zapalenia jamy ustnej (VSV) jako wektora szczepionek przeciwwirusowych
Wirus pęcherzykowatego zapalenia jamy ustnej (vesicular stomatitis virus - VSV), należący do rodziny Rhabdoviridae, jest obiecującym wektorem wirusowym wykorzystywanym podczas opracowywania szczepionek przeciwwirusowych...
Is there an effect of folic acid supplementation on the coagulation factors and C-reactive protein concentrations in subjects with atherosclerosis risk factors?
Introduction: Folic acid (FA) may delay the formation of atherosclerotic lesions. Increased plasma levels of von Willebrand factor (VWF) are observed in cardiovascular disease, which leads to higher risk of thrombosis. F...
Urinary cystatin C as a biomarker of renal tubular injury
Cystatin C (cysC) is an endogenous cysteine peptidase (proteinase) inhibitor that has been intensively investigated as a biomarker of kidney function for many years. It is freely filtered at the kidney glomerulus because...
Renaturacja in vitro białek zakumulowanych w ciałach inkluzyjnych
Rekombinowane białka i enzymy dzięki ich heterologicznej ekspresji w prokariotycznych systemach ekspresyjnych są powszechnie wykorzystywane w diagnostyce, medycynie i przemyśle. Wysoki poziom ekspresji obcych białek w ko...