Vitamin E-like molecules potentiate the curcumin-induced suppression of Caco-2 cell proliferation
Journal Title: International Journal of Pharmacological Research - Year 2016, Vol 6, Issue 1
Abstract
We previously reported that curcumin inhibited the proliferation of a human colorectal cancer cell line Caco-2 by both apoptosis and G2/M cell cycle arrest. A variety of biological functions of curcumin have been suggested to be involved in its modulatory capacity to oxidative stress. The aim of this study was to investigate the modulation of antioxidants, N-acetyl-L-cysteine (NAC), a-tocopherol (TOC) and trolox, on the suppression of Caco-2 cell proliferation via G2/M cell cycle arrest induced by curcumin. NAC (2 mM) reduced the curcumin-induced suppression of Caco-2 proliferation. Inversely, both TOC (0.2 mM) and trolox (0.2 mM) potentiated the curcumin effect. Trolox at the same concentration amplified both G2/M cell cycle arrest and p21 elevation induced by curcumin independent of oxidative stress status. These results suggest that Vitamin E-like molecules have the potential to amplify the inhibitory effect of curcumin on Caco-2 proliferation through reactive oxygen species-independent cell cycle modulation, and could offer new insights for preventive measures against colorectal cancer incidence.
Authors and Affiliations
Tetsuya Kohda, Satoru Sakuma, Yohko Fujimoto
Keywords
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- EP ID EP435220
- DOI 10.7439/ijpr.v6i1.2802
- Views 81
- Downloads 0
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