Active Probe Emitting HF Electromagnetic Fields and Piezoelectric Emissions in Association with Local Carbon Nanotubes : Preliminary Tests in C6 Glioma Cell Death Induction: A Possible Application in Glioblastoma Therapeutics ?
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 14, Issue 3
Abstract
Glioblastoma are malignant tumors of the central nervous system with generally a lethal issue within 15 months whatever the classical therapeutics. Several studies showed promising results using alternative electric or magnetic fields, or nanoparticles (main-ly iron) combined with an alternative magnetic field. Besides, Carbon Nanotubes (CNTs) have very special physicochemical properties potentially synergistic with non-ionizing ra-diation (EMF, including ultrasound from a piezo component) exposure. The aim of this first note was to the effects of a co-exposition from carbon nanotubes and electromagnetic field on an in vitro C6 glioma model growth and viability, using model probe associating EMF (100KHz, square signal, 10Vpp) and piezo emission with a local CNTs deposit. A strong synergic effect between EMF and CNTs as the C6 cell population decrease with these two factors. Respectively, 10%, 25% and 51% population decrease for the Sham / Field, Sham / Nano and double exposed group compared to the control group. However, the survival rate of the cells is poorly affected after 72h exposure time (more than 90% survival rate). These promising results should be used to a miniaturized implantable probe center in or-der to propose a new therapeutic approach using an intra tumoral catheter (including an EMF emitter), allowing the distribution of CNTs (or chemotherapy) using the convective infusion technique.
Authors and Affiliations
Debouzy JC, Crouzier D, Ballester B, Foerster M
Keywords
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- EP ID EP585919
- DOI 10.26717/BJSTR.2019.14.002563
- Views 170
- Downloads 0
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