CRISPR Technology Challenge Facing the Numerical Integrity of Whole Human Genome DNA
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2017, Vol 1, Issue 4
Abstract
Background: Global analysis of 3 human genomes of increasing levels of evolution (Neanderthal /Sapiens Build34 / Sapiens hg38) reveals 2 levels of numerical constraints controlling, structuring and optimizing these genome’s DNA sequences. A global constraint - called “HGO” for “Human Genome Optimum” - optimizes the genome at its global scale. The same operator applied to each of the 24 individual chromosomes reveals a hierarchical structure of these 24 chromosomes. Results: Then analysing the single strand DNA CG / TA proportions at whole chromosomes and genome scale reveals strong fine-tuned numerical ratios evidencing the “closure” nature (Varela’s autopoiesis theory) of whole human genomeThanks to the CRISPR (Clustered regularly interspaced short palindromic repeats) technology, it is now possible to locally modify the genomes, and particularly the human genome [1]. Almost simultaneously, the fractal and global structures of the human genome were demonstrated [2]. In such a context, apart from ethical questions, can a local technology as powerful as CRISPR be applied, ignoring its possible effect on the possible global and long-range equilibrium and balancing at the chromosome scale or even the entire genome scale? For more than 25 years, we have been looking for possible global, even numerical, structures that would organize DNA, genes, chromosomes and even whole genomes [3-6].We have already demonstrated a numerical structure at the scale of each human chromosome as well as on the whole genome [7-15]. In [10] we have already highlighted this numerical value of 0.6909830056, the HGO in this article: it controls the population of triplets codons analysing single stranded DNA sequence from the whole human genome
Authors and Affiliations
Jean-claude Perez
Keywords
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- EP ID EP566615
- DOI 10.26717/BJSTR.2017.01.000324
- Views 199
- Downloads 0
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