FORMULATION AND EVALUATION OF PRAVASTATIN SODIUM IMMEDIATE RELEASE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 5
Abstract
The aim of present investigation is to develop immediate release formulation of Pravastatin sodium for oral drug delivery by using suitable concentration of superdisintegrants. Croscarmellose sodium (AC-DI-SOL), povidone, MCC, Magnesium oxide, magnesium stearate were used to formulate the Immediate release tablet. Croscarmellose sodium was used as superdisintegrant and povidone was used as a binder to control the release of drug. Optimization of superdisintegrant concentration that can control the release of the drug as like the hypothetical release profile was based on release profile of the prepared trials. The Optimized batch F10 was showed good tablet properties like hardness (85-100N), thickness (5.2mm), friability (NIL) and nearly similar drug release profile to the hypothetical drug release profile of the innovator product. The optimized batch was also kept for accelerated stability study which showed no change in either physical appearance, drug content & drug release profile after storage at 40oC/75% RH for 2 months. It is concluded from the present investigation that Pravastatin sodium Immediate release tablet can be successfully formulated using combination of 15 mg (3.75%) Croscarmellose sodium and 8 mg (2%) Povidone. The Optimized formulation display better immediate release in 30 minutes.
Authors and Affiliations
Pinate Devanand , Ravikumar , Mahesh Kumar , A Senthil , Rahul Raut , V B Narayanaswamy
Keywords
Related Articles
- EP ID EP124953
- DOI -
- Views 133
- Downloads 0
A REVIEW ON PHARMACEUTICAL PROCESS VALIDATION
Validation is one of the important steps in achieving and maintaining the quality of the final product. Validation of the individual steps of the process is called process validation. The process is developed in such a w...
A PRELIMINARY STUDY ON THE EFFECTS OF PETROLEUM ETHER & ALCOHOLIC BARK EXTRACT OF Anthocephalus cadamba (Roxb.) MIQ. IN ACUTE AND CHRONIC IN-VIVO INFLAMMATORY RAT MODELS
In order to appraise the traditional use of Anthocephalus cadamba, the petroleum and alcoholic extracts of stem bark of Anthocephalus cadamba, were investigated for their acute and chronic anti-inflammatory activity. The...
EVALUATION OF ANTIMICROBIAL ACTIVITY AND PRELIMINARY PHYTO-CHEMICAL STUDIES ON WHOLE PLANT OF STACHYTARPHETA JAMAICENSIS (L.)VAHL
The antimicrobial activity and preliminary phyto-chemical studies on whole plant of Stachytarpheta jamaicensis were evaluated. The shade dried and coarsely powdered plant was successively extracted with n-hexane, chloro...
SIMULTANEOUS ESTIMATION OF TELMISARTAN AND AMLODIPINE BY UV SPECTROPHOTOMETRIC METHOD USING MULTI COMPONENT MODE OF ANALYSIS
A simple, specific, precise and accurate spectrophotometric method has been developed for the simultaneous estimation of Telmisartan and Amlodipine by multi component mode of analysis. For this, simultaneous equation met...
EUPHORBIA NERIIFOLIA LINN: A PHYTOPHARMACOLOGICAL REVIEW
Euphorbia neriifolia is an herb extensively used in the Indian system of medicine; it is a small deciduous tree of the family Euphorbiaceae. As a tree having number of branches so as Neriifolia having tramondous uses. As...